糖皮质激素治疗结核性胸膜炎的疗效及对炎症细胞因子的影响

Curative Effect of Glucocorticoid in Treatment of Tuberculous Pleuritic and Effect on the Inflammatory Cell Factors

目的研究糖皮质激素治疗结核性胸膜炎的临床疗效及对炎症细胞因子水平的影响。方法回顾性分析该院2014年1月—2016年8月收治的86例结核性胸膜炎患者临床资料,根据治疗方法不同进行分组,将常规治疗的40例患者纳入对照组,常规治疗+糖皮激素治疗的46例纳入观察组,对比两组患者胸腔积液吸收时间、全身症状缓解时间、住院时间、IL-6、IL-8含量,并统计治疗总有效率。结果观察组胸腔积液吸收时间、全身症状缓解时间、住院时间分别为(18.54±3.89)、(6.92±2.34)、(23.91±3.73)d,均较对照组显著缩短(P<0.05);观察组治疗后的IL-6和IL-8分别为(73.24±15.32)、(167.43±152.54)pg/m L,较对照组显著下降(P<0.05);观察组治疗总有效率为97.83%,与对照组的72.50%比较显著提高(P<0.05)。结论糖皮激素治疗结核性胸膜炎疗效确切,可显著缩短患者症状缓解时间和住院时间,抑制胸腔局部免疫细胞,提高临床疗效,值得推广。

Objective To research the curative effect of glucocorticoid in treatment of tuberculous pleuritic and effect on the inflammatory cell factors. Methods 86 cases of patients with tuberculous pleuritic admitted and treated in our hospital from January 2014 to August 2016 were selected and divided into two groups according to different treatment methods, the control group with 40 cases adopted the routine treatment, while the observation group with 46 cases adopted the routine treatment and glucocorticoid, and the pleural effusion absorption time, relief time of general symptoms, length of stay, contents of IL-6 and IL-8 were compared between the two groups, and the total treatment effective rate was counted. Results The pleural effusion absorption time, relief time of general symptoms, length of stay in the observation group were respectively（18.54±3.89）,（6.92±2.34）,（23.91±3.73）d, which were obviously shortened compared with those in the control group（P〈0.05）,after treatment, the IL-6 and IL-8 in the observation group were respectively（73.24±15.32） and（167.43±152.54）pg/m L,which were obviously decreased compared with those in the control group（P〈0.05）, and the total treatment effective rate in the observation group was obviously increased compared with that in the control group（97.83% vs 72.50%）（P〈0.05）.Conclusion The curative effect of glucocorticoid in treatment of tuberculous pleuritic is definite, which can obviously shorten the relief time of symptoms and length of stay, suppress the local chest immune cell and improve the clinical curative effect,and it is worth promotion.