β_2受体激动剂与抗胆碱能药物治疗COPD临床观察及药学分析

Clinical observation and pharmaceutical analysis of β_2 receptor agonist and anticholinergic drugs in the treatment of COPD

目的:探究β_2受体激动剂与抗胆碱能药物治疗慢性阻塞性肺疾病(COPD)患者的临床疗效并分析其药学成分。方法:收治COPD患者162例,随机分两组,对照组给予常规治疗,观察组在此基础上联合β_2受体激动剂与抗胆碱能药物治疗,对比两组患者临床疗效及肺功能改善情况。结果:观察组患者治疗有效率90.12%,与对照组的72.84%相比较高,且差异有统计学意义(P<0.05);观察组患者心功能状况显著优于对照组(P<0.05);观察组患者不良反应与对照组相比,差异无统计学意义(P>0.05)。结论:β_2受体激动剂与抗胆碱能药物对COPD患者疗效确切,且可显著改善心功能状况,不会增加不良反应。

Objective:To investigate the clinical observation and pharmaceutical analysis of β_2receptor agonist and anticholinergic drugs in the treatment of COPD.Methods:162 patients with COPD were selected.They were randomly divided into the two groups.The control group was given conventional treatment.On this basis,the observation group was treated withβ_2receptor agonist and anticholinergic drugs.The clinical efficacy and the improvement of pulmonary function were compared between groups.Results:The effective rate of the observation group was 90.12% higher than that of the control group of 72.84%,and the difference was statistically significant(P<0.05).The cardiac function of the observation group was significantly better than that of the control group(P<0.05).There was no significant difference of adverse reaction between the observation group and the control group(P>0.05).Conclusion:Theβ_2receptor agonist and anticholinergic drugs are effective in the treatment of patients with COPD,and can significantly improve the cardiac function and not increase adverse reactions.