Abnormal Alterations of Cortical Thickness in 16 Patients with Type 2 Diabetes Mellitus： A Pilot MRI Study

这研究的目的是调查服的外皮的厚度的目的用一个整个大脑在类型 2 糖尿病 mellitus ( T2DM )变化基于大脑印射系统的外皮的厚度磁性的回声成像( MRI ) .Methods 高度分辨率三维的T1加权的快宠坏的坡度记起的回响先生图象从 16 个病人被获得与 T2DM ，以及从 16 正常控制。外皮的厚度印射的整个大脑被产生，并且每个大脑区域的外皮的厚度用由 Freesurfer 软件的一个自动化标记的系统根据兴趣(ROI ) 的旋转基于的区域是计算的。我们作为 covariates 由协变性的分析在每个大脑区域把吝啬的外皮的厚度与年龄和性别作比较。在整个大脑上的外皮的厚度的地区性的差别被吝啬的外皮的厚度分析显示出的基于表面的外皮的 thickness.Results 的分析比较在有 T2DM 的病人的双边的大脑(左：2.

Objective The aim of this study is to investigate the cerebral cortical thickness changes in type 2 diabetes mellitus （T2DM） using a whole brain cortical thickness mapping system based on brain magnetic resonance imaging （MRI）. Methods High resolution three-dimensional T1-weighted fast spoiled gradient recalled echo MR images were obtained from 16 patients with T2DM, as well as from 16 normal controls. The whole brain cortical thickness maps were generated, and the cortical thickness of each brain region was calculated according to gyral based regions of interest （ROI） using an automated labeling system by the Freesurfer software. We compared mean cortical thickness at each brain region by the analysis of covariance with age and sex as covariates. The regional difference of the cortical thickness over the whole brain was compared by the analysis of surface-based cortical thickness. Results Mean cortical thicknesses analysis showed bilateral cerebrum in the patients with T2DM （left： 2.52±0.07 mm; right： 2.51±0.08 mm） were significant thinner than those in the normal controls （left： 2.56±0.09 mm; right： 2.56±0.09 mm） （both P〈0.05）. Regional cortical thinning in T2DM was demonstrated in the paracentral lobule, postcentral gyrus, lateral occipital gyrus, lingual gyrus, precuneus, superior temporal gyrus, middle temporal gyrus, inferior temporal gyrus and posterior cingulate gyrus, compared to the normal controls. The cortical thickness of left middle cingulate and right inferior temporal gyrus were negatively correlated with the disease course. Conclusion A widespread cortical thinning was revealed in patients with T2DM by the analysis of brain cortical thickness on MR. Our finding supports the idea that T2DM could lead to subtle diabetic brain structural changes.