阿托伐他汀治疗老年缺血性卒中合并高脂血症患者的疗效与安全性

Efficacy and safety of atorvastatin in the treatment of elderly patients with ischemic stroke complicated with hyperlipidemia

目的探讨不同剂量阿托伐他汀对老年缺血性卒中合并高脂血症患者的疗效及安全性。方法选择自2014年5月~2016年8月于北京市第二医院住院接受治疗的缺血性卒中合并高脂血症患者120例。将患者随机分成低剂量与高剂量两组,每组60例,其中低剂量组给予阿托伐他汀10 mg/d,高剂量组给予阿托伐他汀20 mg/d口服,两组患者均给予常规基础药物治疗。测定所有患者在治疗前和治疗8周后血脂等指标变化情况,并比较两组患者的临床疗效及不良反应发生情况。结果治疗8周后,两组患者的总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平均较治疗前明显下降(P<0.05);低剂量组总有效率为68.3%,高剂量组总有效率为88.3%,高剂量组治疗效果优于低剂量组(P<0.05);其不良反应发生率两组比较无统计学意义(P>0.05)。结论高剂量阿托伐他汀治疗老年性缺血性卒中合并高脂血症效果明显,且安全性良好。

Objective To investigate the clinical efficacy and safety of different doses of atorvastatin in elderly patients with ischemic stroke complicated with hyperlipidemia. Method 120 hospitalized patients with ischemic stroke complicated with hyperlipidemia from May 2014 to August 2016. All patients were randomly divided into two groups. Besides treatment with conventional drugs, patients in low dose group were given 10 mg atorvastatin per day, while patients in high dose group were given 20 mg atorvastatin per day. The changes of blood lipid and other indexes were measured before and after treatment for 8 weeks. The clinical efficacy and adverse reaction were compared between the two groups. Results After treatment for 8 weeks, the levels of total cholesterol （TC）, low density lipoprotein cholesterol （LDL-C） and high density lipoprotein cholesterol （HDL-C） in the two groups were significantly lower than those before treatment （P〈0.05）. The total effective rate was 68.3% in the low dose group and 88.3% in the high dose group. The therapeutic effect in the high dose group was better than that in the low dose group （P〈0.05）. The incidence of adverse reactions was not statistically different between the two groups （P〉0.05）. Conclusion High-dose atorvastatin is effective in the treatment of elderly patients with ischemic stroke complicated by hyperlipidemia, with good safety.