hs-CRP、Hcy、IMA、H-FABP检测对急性冠脉综合征危险分层的意义

Clinical significance of detection of hs-CRP,Hcy,IMA and H-FABP in risk stratification of acute coronary syndrome

目的分析高敏C反应蛋白(hs-CRP)、同型半胱氨酸(Hcy)、缺血修饰白蛋白(IMA)、心型脂肪酸结合蛋白(H-FABP)检测对急性冠脉综合征危险分层的意义。方法选择2015年5月~2016年4月于陕西省西安市第九医院进行诊治的急性冠脉综合征患者300例。按照GRACE危险评分表对其进行危险分层,分为低危组(85例)、中危组(150例)和高危组(65例),并选择同期体检健康者100例归入对照组。检测所有入选者hs-CRP、Hcy、IMA、H-FABP水平。结果对照组、低危组、中危组和高危组hs-CRP、IMA、H-FABP水平呈递增趋势,差异有统计学意义(P均<0.05)。与对照组比较,低危组、中危组和高危组Hcy水平均升高,差异有统计学意义(P均<0.05)。中危组和高危组Hcy水平均低于低危组,差异有统计学意义(P均<0.05)。结论急性冠状动脉综合征患者hs-CRP、IMA、H-FABP水平随危险程度的加重而升高,在急性冠脉综合征危险分层中具有重要的价值。

Objective To analyze the clinical significance of detection of high-sensitivity C-reactive protein （hs-CRP）, homocysteine （Hcy）, ischemia modified albumin （IMA） and heart-type fatty acid-binding protein （H-FABP） in risk stratification of acute coronary syndrome （ACS）. Methods ACS patients （n=300） were chosen from the Ninth Hospital in Xi’an City of Shaanxi Province from May 2015 to Apr. 2016. All patients were divided, according to GRACE risk scoring, into low-risk group （n=85）, medium-risk group （n=150） and high-risk group （n=65）, and meanwhile health controls （n=100） were chosen into control group. The levels of hs-CRP, Hcy, IMA and H-FABP were detected in all groups. Results The levels of hs-CRP, IMA and H-FABP showed an ascending trend in all groups （all P〈0.05）. The level of Hcy increased in low-risk group, medium-risk group and high-risk group compared with control group （all P〈0.05）. The level of Hcy was lower in medium-risk group and high-risk group than that in low-risk group （all P〈0.05）. Conclusion The levels of hs-CRP, IMA and H-FABP will increase as ACS risk increases, and they have important values in risk stratification of ACS.