肠道上皮细胞再生修复与恶性转化的研究现状

Self renewal,repair and malignant transformation of intestine epithelial cells

肠黏膜慢性炎症是肠道肿瘤发展的重要组成部分。近期,对肠道肿瘤患者的高通量测序研究发现了一个潜在的、以伤口愈合和先天免疫基因过表达为特征的结肠癌分子亚型,它提示了一种可能依赖于炎症细胞和细胞因子的肿瘤发展机制,增强了我们对细胞恶性转化的理解,以及突出了抗炎在肿瘤治疗中的作用。本文将对正常的肠黏膜更新、伤口愈合和恶变的机制做一综述。

Chronic inflammation of intestine mucosal has been considered as a critical component of colorectal cancer development. Recently, the studies based on high throughput sequencing of colorectal cancer pa-tients released a potential molecular subtype of colorectal cancer, characterized by wound healing and innate im-mune genes. It suggests that a probably mechanism described by a subset of cells that may be dependent on in- flammatory cells and cytokines of tumor development, extremely expanding our insight of cell malignant transfor-mation ,and highlight the anti - inflammation treatment. This article will review the normal mechanism of intestine mucosal renewal, wound healing and malignant transformation.