受体酪氨酸激酶AXL在肿瘤中的研究进展

Research progress of receptor tyrosine kinase AXL in tumor

AXL是TAM受体酪氨酸激酶家族中的一员,AXL已经被证实与肺癌、乳腺癌、甲状腺癌、前列腺癌和胰腺癌等多种癌症有关。最新证据显示,AXL可促进多种肿瘤的生长、侵袭、转移,其抑制剂可抑制肿瘤形成,这说明AXL可能成为抗肿瘤治疗的潜在靶点,AXL激酶抑制剂的应用可能成为抗肿瘤治疗的新策略。本文对AXL与肿瘤方向的研究进展做一综述。

AXL is a member of the TAM receptor tyrosine kinase family, and AXL has been shown to be associated with a variety of cancers such as lung cancer, breast cancer, thyroid cancer, prostate cancer and pancre-atic cancer. The latest evidence suggests that AXL can promote the growth, invasion and metastasis of various tumors, and its inhibitors can also inhibit tumor formation, suggesting that AXL may be a potential target for anti - tumor therapy, and the use of AXL kinase inhibitors may become the new strategy of anti - tumor therapy. This ar-ticle reviews the progress of AXL and tumor.