1型单纯疱疹病毒抗体与阿尔茨海默病的关联研究

he relationship between antibody to herpes simplex virus type 1 and Alzheimer′s disease

目的 探讨老年人群1型单纯疱疹病毒（HSV-1）感染与阿尔茨海默病（AD）的关联性。方法 共入组AD患者101例，男74例，女27例，年龄77~93岁。正常对照组107例，男81 例，女26例，年龄71~89岁。采用认知障碍简明评价量表（Cog-12）、简易智力状态检查量表（MMSE）、蒙特利尔认知评估量表（MoCA）等进行认知功能评分。应用ELISA 法测定HSV-1抗体、血浆Tau 蛋白。结果 两组间年龄、性别构成的差异无统计学意义。AD组HSV-1抗体阳性率为79.2%,对照组为58.0%，AD组明显高于对照组，差异有统计学意义（P〈0.05）。回归分析显示HSV-1抗体阳性、糖尿病、高胆固醇血症等是AD患病的危险因素。结论 HSV-1感染是AD患病可能的危险因素之一；外周血浆Tau蛋白水平与AD患病无明显关联。

Objective To discuss the relationship between herpes simplex virus type 1 （HSV-1） infection and Alzheimer disease （AD） in elderly patients. Methods A total of 101 AD patients （74 men and 27 women aging from 77 to 93） were included. Meanwhile, another 107 healthy subjects （81 men and 26 women aging from 71 to 89） were selected as a control group. Their cognitive functions were assessed according to the Alzheimer Disease Assessment Scale-Cognitive 12 （Cog-12）, the Montreal Cognitive Assessment （MoCA）, and the Mini Mental Status Examination （MMSE）. Antibody to HSV-1 and plasma tau protein were detected by ELISA. Results There was no statistical difference as to age and gender between the two groups. Group AD showed a higher positive rate of antibody to HSV-1 than the control group （79.2% vs. 58.0%, P〈0.05）. According to logistic regression analysis, antibody to HSV-1, diabetes, and hyperlipidemia were risk factors for the development of AD. Conclusions HSV-1 infection is a risk factor to Alzheimer disease. There was no relationship between the level of tau protein in the peripheral blood plasma and AD.