细胞免疫治疗联合节拍化疗在晚期三阴性乳腺癌中的疗效观察

Observation of the efficacy of cellular immunotherapy combined with metronomic chemotherapy in the treatment of advanced triple negative breast cancer

目的 观察细胞免疫疗法与节拍化疗相结合对晚期三阴性乳腺癌患者进行治疗的安全性及有效性。方法 将59例复发转移的晚期三阴性乳腺癌患者随机分为2组，观察组30例，接受细胞免疫治疗联合节拍化疗（卡培他滨＋环磷酰胺），对照组29例，单纯接受节拍化疗。结果 观察组疾病控制率高于对照组，但差异无统计学意义（P＞0.05）。观察组严重不良反应：手足综合征、胃肠道反应、骨髓抑制发生率低于对照组，其中胃肠道反应、骨髓抑制发生率2组差异有统计学意义（P＜0.05）。观察组CD3＋、CD4＋/CD8＋、自然杀伤T细胞（NKT）治疗后与治疗前比较，差异均有统计学意义（P＜0.05）。结论 细胞免疫治疗联合节拍化疗治疗晚期三阴性乳腺癌有效，且不良反应低，可耐受。

Objective To observe the clinical efficacy and safety of cellular immunotherapy combined with metronomic chemotherapy in the treatment of advanced triple negative breast cancer. Methods A total of 59 patients with advanced metastatic triple negative breast cancer were divided into two groups： an observation group （n=30） which was provided with cellular immunotherapy combined with metronomic chemotherapy （capetabine＋cyclophosphamidum） and a control group （n=29） which received metronomic chemotherapy alone. Results The observation group produced a higher disease control rate than the control group, without statistical differences （P〉0.05）. The incidences of hands-feet syndrome, gastrointestinal reaction and myelosuppression were lower in the observation group than that of the control group, where statistical difference was found as to the incidences of gastrointestinal reaction and myelosuppression between the two groups （P＜0.05）. For the observation group, the ratios of CD3＋, CD4＋/CD8＋ and NKT were remarkably different after treatment compared with those before treatment （P＜0.05）. Conclusions Cellular immunotherapy combined with metronomic chemotherapy is effective to treat advanced triple negative breast cancer, with low toxicity and good tolerance.