应用电子束辐射技术的抗菌改性聚酯纳米纤维膜

Antibacterial modification of polyester nanofibrous membranes by electron beam irradiation technique

为制备一种高效抗菌生物材料,以生物可降解材料聚(3-羟基丁酸酯-co-4-羟基丁酸酯)(P(3HB-4HB))和聚己二酸/对苯二甲酸丁二酯(PBAT)为基材,合成了一种新型含有季铵基团的卤胺抗菌剂单体;采用静电纺丝技术制备出P(3HB-4HB)/PBAT纳米纤维膜;利用电子束辐射技术将合成的单体接枝共聚到纳米纤维膜,最后经次氯酸钠氯化得到抗菌纤维膜。探讨了P(3HB-4HB)、PBAT组成对纤维膜表面形貌的影响,以及辐射量、单体浓度对纤维膜含氯量的影响,同时分析了抗菌纤维膜的耐紫外稳定性、储存稳定性。结果表明:P(3HB-4HB)/PBAT抗菌纳米纤维膜在5 min内即可将金黄色葡萄球菌和大肠杆菌全部杀死,显示出优异的抗菌性能,实现了卤胺抗菌剂和化学惰性材料的共价键合作用,有望应用于食品包装、生物医学等领域。

In order to prepare an efficient antibacterial biomaterials,an innovative N-halamine monomer containing quaternary ammonium group was synthesized and grafted onto the poly（ 3-hydroxybutyrate-co-4-hydroxybutyrate）（ P（ 3HB-4HB）） and poly（ butylene adipate-co-terephthalate）（ PBAT） nanofibrous membranes that were generated by electrospinning,and finally the grafted nanofibrous membranes were chloridized with sodium hypochlorite to obtain antibacterial nanofibrous membranes. The influence of the composition of P（ 3HB-4HB） and PBAT on surface morphologies of membranes and the influence of the irradiation dose and the concentration of monomer on the content of oxidative chlorine were studied. The UV light stability and the storage stability of the antibacterial nanofibrous membranes were also investigated. The results show that the P（ 3HB-4HB）/PBAT antibacterial nanofibrous membranes can kill both S. aureus and E. coli within 5 min,showing powerful antibacterial performance,realize the covalent bonding effect between N-halamine antibacterials and chemical inert materials,and have great potential in fields of food packaging and biomedicines.