C反应蛋白在急性心肌梗死溶栓后发生再灌注损伤的预测价值

Predictive value of C-reactive protein in reperfusion injury after thrombolytic therapy in patients with acute myocardial infarction

目的探讨C反应蛋白在急性心肌梗死溶栓治疗后发生再灌注损伤的预测价值。方法选取107例进行溶栓治疗的急性心肌梗死患者。根据入选标准和剔除标准在42例发生了心肌再灌注损伤的患者中选出符合条件的35例为实验组,在65例溶栓后未发生心肌再灌注损伤的患者中选出符合条件的患者35例为对照组。观察2组患者溶栓前C反应蛋白和溶栓后心肌再灌注损伤发生的相关性,并研究其预测价值。结果 2组患者溶栓前C反应蛋白均有升高,但C反应蛋白明显升高的患者溶栓后出现心肌再灌注损伤的发生率均高于C反应蛋白升高较低的患者(P<0.05)。结论 C反应蛋白明显升高对急性心肌梗死患者溶栓后发生心肌再灌注损伤的风险有预测价值。

Objective To explore the value of C - reactive protein predicting occurrence of reperfusion injury after thrombolysis therapy of acute myocardial infarction. Methods 107 cases of acute myocardial infarction receiving thrombolysis therapy were collected. According to selection and eliminati6n standards,35 cases selected from 42 cases who had occurred reperfusion injury were as the test group and 35 cases were selected from 65 cases who had no reperfusion injury were as the control group. The correlation between the C - creative protein before thrombolysis and the occurrence rate of reperfusion injury after thrombolysis in both groups were observed. The predictive value of C - reactive protein was examined. Results The C - reactive protein in the two groups both increased before throm- bolysis. However,the occurrence rate of reperfusion injury after thrombolysis was much higher among patients whose C - reactive protein increase. It was more significant （P 〈 0.05） and the difference was statistically significant. Conclusions Significant increase of C - reactive protein is a sound predictor of risks of reperfusion injury after thrombelysis of acute myocardial infarction.