FOXP1在结直肠癌中的表达及意义

Expression and implication of FOXP1 in human colorectal cancer

目的探讨FOXP1(fork-head box protein 1)蛋白在结直肠癌中的表达及意义。方法采用免疫组化染色方法检测120例结直肠癌及20例癌旁组织中FOXP1蛋白的表达水平。结果 FOXP1蛋白在结直肠癌中表达率为68.3%(82/120),显著高于其在癌旁组织的表达[10.0%(2/20),P<0.05];FOXP1蛋白表达率分别在淋巴结转移更多、肿瘤分化程度更低、TNM分期更高的结直肠癌分组阳性率更高,差异有统计学意义(P<0.05);FOXP1蛋白表达率在不同性别、年龄、肿瘤大小和肿瘤部位的结直肠癌分组间差异无统计学意义(P>0.05)。结论 FOXP1蛋白表达与结直肠癌发生发展密切相关,FOXP1蛋白高表达提示肿瘤恶性程度高,预后差。

Objective To investigate the expression of FOXP1 in human colorectal cancer and its significance. Methods Expression of FOXP1 was detected with immunohistochemistry assay in 20 cases of cancer adjacent tissues and 120 cases of colorectal cancer tis- sues. Results The positivity rate of FOXP1 protein expression in human colorectal cancer tissues was significantly higher than that of cancer adjacent tissues （68.3% vs 10. 0%, P 〈 O. 05 ）. The expression of FOXP1 in colorectal cancer was higher in the more lymph node metastasis, the poorer tumor differentiation and the higher TNM staging colorectal cancer tissues （ P 〈 O. 05 ）, and there was no significant difference between patients with different sex, age, tumor size and tumor location（P 〉 0. 05）. Conclusion The expression of FOXP1 protein is closely related to the occurrence and development of colorectal cancer. The high expression of FOXP1 protein may predict a high degree of malignancy and Door oroenosis.