益生菌与免疫球蛋白口服辅助治疗儿童轮状病毒性肠炎的疗效对比分析

Comparison of the Efficacy of Probiotics and Oral Immunoglobulin as the assistance in the Treatment of Rotavirus Enteritis in Children

为比较益生菌与免疫球蛋白口服辅助治疗儿童轮状病毒性肠炎的疗效，将120例轮状病毒性肠炎患儿随机分为3组，即益生菌组、免疫球蛋白组和对照组。3组患儿均接受相同的基础治疗（包括口服蒙脱石散、补液和对症治疗）。在此基础上，益生菌组予以双歧杆菌乳杆菌三联活菌片口服，每次0．5g，每天3次；免疫球蛋白组予以免疫球蛋白口服，每次1．0g，每天3次；对照组口服安慰剂。对比3组患儿治疗后不同时点腹泻情况、菌群失调及细菌感染情况。结果显示，3组患者治疗后腹泻次数均依次减少。治疗第3天开始益生菌组和免疫球蛋白组腹泻次数均明显低于对照组（P〈0．05）；治疗第5、7、9天益生菌组和免疫球蛋白组菌群失调、细菌感染情况均明显优于对照组（P〈0．05）；但益生菌组和免疫球蛋白组腹泻次数和菌群失调情况比较差异均无统计学意义（P〉0．05）。免疫球蛋白组疗程[（4．6±1．3）d]明显短于益生菌组和对照组[（5．6±1．7）d和（6．0±1．8）d]（P〈0．05）。结果表明，辅助应用益生菌和免疫球蛋白均能有效缓解轮状病毒性肠炎患儿肠道菌群失调，预防继发感染，但益生菌不能缩短疗程，而免疫球蛋白可以。

In order to compare the efficacy of probiotics and oral immunoglobulin in the treatment of rotavirus enteritis in children, 120 children with rotavirus enteritis were randomly divided into three groups： probiotics group, immunoglobulin group and control group. Three groups of children all received the same basic treatment （including oral montmorillonite powder, fluid infusion and symptomatic treatment）. On the basis of this, the probiotics group was given oral administration of live combined Bifidobacterium and Lactobacillus tablets, each time 0.5 g, 3 times a day; immunoglobulin group was given oral immunoglobulin, each time 1.0 g, 3 times a day; control group was given oral placebo.The conditions of diarrhea,dysbaeteriosis and bacterial infection in three groups at different time points were compared. As results, the number of diarrhea was decreased successively in three groups after treatment. The number of diarrhea in the probiotics group and the immunoglobulin group was significantly lower than that in the control group on the third day of treatment （ P 〈0.05）. In dysbacteriosis and bacterial infection ,the probiotics group and the immunoglobulin group were significantly better than the control group on the 5th, 7th and 9th day of treatment, P 〈0.05 ; but in the number of diarrhea and dysbacteriosis of probiotics group and immunoglobulin group,there was no statistical difference, （P 〈0.05）.In treatment course,the immunoglobulin group [（4.6±1.3） d; was significantly shorter than that in the probiotics group [（5.6±1.7） d] and the control group [（6.0±1.8） d, P 〈0.05].The results show that the auxiliary application of probiotics and immunoglobulin can effectively alleviate the intestinal dysbacteriosis in children with rotavirus, prevent secondary infection.But probiotics can not shorten the course of treatment,while immunoglobulin can.