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地奈德水性凝胶抗炎与皮肤刺激性的实验观察

Experimental observation of the anti-inflammatory effect of desonide aqueous gel and its skin irritation
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摘要 目的:研究地奈德水性凝胶的抗炎作用和皮肤刺激性,了解其药效和安全性。方法:采用小鼠耳廓肿胀法、小鼠足爪肿胀法、磷酸组胺致痒法和豚鼠、新西兰大白兔的皮肤刺激性试验等模型和方法,观察地奈德水性凝胶对实验性动物抗炎作用、止痒作用的效果,观察其皮肤刺激性。结果:地奈德水性凝胶能有效地抑制二甲苯引起的小鼠耳廓肿胀、鸡蛋清引起的小鼠足趾肿胀,明显增加豚鼠耐受磷酸组胺的致痒阈,疗效比市售乳膏(力言卓)略好,对完好和破损皮肤均无刺激性。结论:地奈德水性凝胶抗炎止痒效果好于市售乳膏剂,而且无刺激性,是一种新的糖皮质激素外用制剂。 Objective: To study the anti-inflammatory effect of desonide aqueous gel and its skin irritation,so as to learn more about its efficacy and safety. Methods: Such models and methods as the mouse ear swelling,mouse paw swelling,itching caused by histamine phosphate method,and guinea pigs,rabbits and other skin irritation were used to observe the anti-inflammatory and antipruritic effects of desonide aqueous gel on experimental animals. Results: Desonide aqueous gel can effectively inhibit xylene-induced ear edema in mice,paw edema induced by egg mice,significantly increased guinea pigs' tolerance to histamine-induced itch threshold phosphate. It was slightly more effective than the commercial desonide cream,and it didn't bring any irritation to the intact and damaged skin. Conclusion: Desonide aqueous gel is better than the commercially available anti-inflammatory and anti-itch creams,with no irritation,and it is expected to become a new topical glucocorticoid preparations.
出处 《华夏医学》 CAS 2017年第2期13-16,共4页 Acta Medicinae Sinica
基金 广西壮族自治区卫生厅科研资助项目(Z2014186)
关键词 地奈德 凝胶 抗炎 皮肤刺激性 desonide gel anti-inflammatory skin irritation
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