血清CRP、CysC、Hcy在糖尿病肾病诊断中的应用

Application of serum CRP,CysC and Hcy to the diagnosis of diabetic nephropathy

目的:探讨血清CRP、Cys C、Hcy在糖尿病肾病诊断中的应用价值。方法:选择我院收治的60例糖尿病肾病患者为研究组,同期在我院体检正常的60例健康人群作为对照组,采集血液标本及尿标本,比较两组CRP、Cys C、Hcy水平的差异。结果:研究组Cys-C水平(3.78±0.56)mg/L、Hcy(35.21±1.56)μmol/L、hs-CRP(85.26±2.59)mg/L明显高于对照组,差异均有统计学意义(P<0.01);研究组3项指标联合检测阳性率91.67%,明显高于3项指标单独检测时的阳性率,差异具有统计学意义(P<0.05)。结论:联合Cys-C、HCY、hs-CRP水平监测在早期糖尿病肾病诊断中具有重要指导意义。

Objective： To investigate clinical value of serum CRP,Cys C and Hcy in the diagnosis of diabetic nephropathy. Methods： 60 patients with diabetic nephropathy in our hospital were selected as the subjects,and another 60 healthy people of the corresponding period were selected as the control group.Blood samples and urine samples were collected and CRP,Cys C and Hcy levels between both groups were compared. Results： The level of Cys-C,Hcy and hs-CRP in the study group were（ 3. 78 ± 0. 56） mg/L,（35.21±1.56） mol/L,and（85.26±2.59） mg/L respectively,significantly higher than those of the control group,which were of statistical differences（ P〈0.01）; the positive rate of the combined detection for the three indicators in the study group was 91.67%,significantly higher than that of separate detection of the three indicators,which were of statistical differences（ P 〈0. 05）. Conclusion： Combined monitoring and detection of Cys-C,HCY and hs-CRP levels have important guiding significance in the early diagnosis of diabetic nephropathy.