多项检测在系统性红斑狼疮患者预后和风险评估中的作用

The role of multiple tests in prognosis and risk assessment of patients with systemic lupus erythematosus

目的探讨血清人附睾蛋白(HE4)、腺苷脱氨酶(ADA)、C-反应蛋白(CRP)、肿瘤特异性生长因子(TSGF)、β2微球蛋白(β2-MG)、甲胎蛋白(AFP)、癌胚抗原(CEA)、CA125、CA19-9、肌酐(CREA)、尿素氮(UREA)、尿酸(UA)、胱抑素C(Cys-C)、铁蛋白(FREE)、皮质醇(COR)、促肾上腺皮质激素(ACTH)水平在系统性红斑狼疮患者预后和风险评估中的作用。方法选取系统性红斑狼疮女性患者60例作为SLE组,另收集60例健康女性体检者为对照组,分别检测。结果 SLE组血清HE4、ADA、β2-MG、ACTH、CREA、FREE、UREA、Cys-C水平均高于对照组,差异有统计学意义(P<0.05)。SLE组血清HE4与β2-MG呈负相关(r=-0.767,P<0.05),与ACTH呈正相关(r=0.714,P<0.05),SLE组血清ACTH与β2-MG呈负相关(r=-0.709,P<0.05)。结论系统性红斑狼疮患者检测人附睾蛋白、β2微球蛋白、铁蛋白、促肾上腺皮质激素在诊疗和预后中有重要意义。

Objective To investigate the role of epididymal protein, adenosine deaminase, C reactive protein, tumor specific growth factor, β2 -microglobulin, alpha fetal protein, cancer embryo antigen, carbohydrate antigen 125, carbohydrate antigen 19 - 9 （ CA19 - 9）, creatinine, urea nitrogen, uric acid, Cystatin C, ferritin, eortisol, adrenocortieotropie hormone in the prog- nosis and risk assessment of patients with systemic lupus erythematosus. Methods 60 female patients suffering from SLE were selected as the case SLE group and 60 cases as the control group. They were detected respectively. Results The levels of HFA, ADA, β2 - MG, ACTH, CREA, FREE, UREA and Cys - C in SLE group were higher than these of the control group, and the differences were statistically significant（ P 〈0.05 ）. HFA was positively correlated with β2 -MG and ACTH in patients with systemic lupus erythcmatosus（r = -0. 767, r =0. 714, P 〈 0.05） ; ACTH and β2 -MG had a negative correlation in pa- tients with systemic lupus erythematosus （ r =- 0.709, P 〈 0.05 ）. Conclusion Detection of human epididymis protein, β2 - mieroglobulin, ferritin, adrenoeorticotropic hormone on patients with systemic lupus erythematosus have important significance in the diagnosis, treatment and prognosis.