锌硒制剂及葡萄糖酸锌治疗小儿抗生素相关性腹泻的疗效对比

Comparison of the effect of zinc and selenium preparation and zinc sulfate on antibiotic associated diarrhea

目的 比较锌硒制剂及葡萄糖酸锌治疗小儿抗生素相关性腹泻的疗效.方法 选择2014年2月至2015年2月120例抗生素相关性腹泻患儿为研究对象,随机分为对照组和观察组,每组60例,对照组患儿采用葡萄糖酸锌治疗,观察组患儿采用锌硒制剂治疗.观察记录所有患儿的治疗有效率、相关症状消失时间、腹泻发生率.结果 观察组治疗有效率为96.67%,明显高于对照组（70.00%）;观察组呕吐、发热、腹泻消失时间明显短于对照组,腹泻发生率明显低于对照组,差异均有统计学意义（P〈0.05）.结论 锌硒制剂治疗小儿抗生素相关性腹泻有较好的临床效果,在治疗有效率、相关症状消失时间、腹泻发生率方面均优于葡萄糖酸锌.

Objective To compare the effect of zinc and selenium preparation and zinc sulfate on antibiotic associated diarrhea in children.Methods From February 2014 to February 2015, 120 cases of antibiotic associated diarrhea were selected as the research objects.The 120 cases were randomly divided into the control group （60 cases） and observation group （60 cases）, the control group were treated with zinc gluconate, the observation group were treated with zinc selenium.The efficiency of all the children, the related symptom disappearance time, diarrhea incidence was observed.Results The effective rate of the observation group was 96.67%, which was significantly higher than that of the control group （70%）.The vomiting, fever, diarrhea disappearance time in the observation group was significantly shorter than those in the control group.The incidence of diarrhea in the observation group （6.67%） was significantly lower than that in the control group （31.67%）, the difference was significant （P〈0.05）.Conclusions Zinc and selenium has good clinical effect on antibiotic associated diarrhea.It is better than the zinc in the efficiency, the related symptoms disappearance time and the diarrhea incidence.