麝香保心丸联合藻酸双酯钠治疗不稳定型心绞痛的疗效观察

Clinical observation of Shexiang Baoxin Pills combined with alginic sodium diester in treatment of unstable angina

目的探讨麝香保心丸联合藻酸双酯钠治疗不稳定型心绞痛患者的临床疗效。方法选取2014年2月—2016年2月天津医科大学总医院收治的不稳定型心绞痛患者126例,随机分为对照组和治疗组,每组各63例。对照组静脉滴注藻酸双酯钠注射液,0.1 g加入到生理盐水500 m L,1次/d。治疗组患者在对照组治疗基础上口服麝香保心丸,2丸/次,3次/d。两组均连续治疗15 d。观察两组患者的临床疗效和心电图疗效,同时比较两组患者治疗前后SAQ评分、心绞痛发作次数和心绞痛持续时间的变化情况。结果治疗后,对照组和治疗组的总有效率分别为80.77%、98.08%;两组心电图总有效率分别为80.95%、96.83%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者SAQ评分均显著升高,心绞痛发作次数和心绞痛持续时间均显著降低,同组治疗前后比较差异有统计学意义(P<0.05);治疗后,治疗组SAQ评分高于对照组,心绞痛发作次数和心绞痛持续时间低于对照组,两组比较差异具有统计学意义(P<0.05)。结论麝香保心丸联合藻酸双酯钠治疗不稳定型心绞痛具有较好的临床疗效,可显著降低心绞痛发作次数和持续时间,具有一定的临床推广应用价值。

Objective To explore the clinical efficacy of Shexiang Baoxin Pills combined with alginic sodium diester in treatment of unstable angina. Methods Children（126 cases） with unstable angina in General Hospital of Tianjin Medical University from February 2014 to February 2016 were randomly divided into control and treatment groups, and each group had 63 cases. Patients in the control group were iv administered with Alginic Sodium Diester Injection, 0.1 g added into normal saline 500 mL, once daily. Patients in the treatment group were po administered with Shexiang Baoxin Pills on the basis of the control group, 2 pills/time, three times daily. Patients in two groups were treated for 15 d. After treatment, the clinical efficacy and electrocardiogram efficacy were evaluated, and the changes of SAQ scores, frequency and duration of angina in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 80.77% and 98.08%, respectively, electrocardiogram efficacies in two groups were 80.95% and 96.83%, and there was difference between two groups（P〈0.05）. After treatment, SAQ scores in two groups were significantly increased, but frequency and duration of angina were significantly decreased, and the difference was statistically significant in the same group（P〈0.05）. After treatment, SAQ score in the treatment group was higher than that in the control group, frequency and duration of angina were lower than those in the control group, and there were differences between two groups（P〈0.05）. Conclusion Shexiang Baoxin Pills combined with alginic sodium diester has significant clinical efficacy in treatment of unstable angina, and can significantly reduce frequency and duration of angina, which has a certain clinical application value.