替勃龙片联合双唑泰泡腾片治疗老年性阴道炎疗效观察

Clinical observation of Tibolone Tablets combined with Metronidazole Clotrimazole and Chlorhexidine Acetate Effervescent Tablets in treatment of senile vaginitis

目的探讨替勃龙片联合双唑泰泡腾片治疗老年性阴道炎的临床疗效。方法选取2016年1月—2016年7月在信阳市第四人民医院接受诊治的老年性阴道炎患者90例,所有患者根据用药方案的不同分为对照组和治疗组,每组各45例。对照组每晚清洁外阴后于阴道深处置入双唑泰泡腾片,1片/次,1次/d。治疗组在对照组基础上口服替勃龙片,1片/次,1次/d。两组患者均连续治疗3个月。观察两组的临床疗效,比较两组的临床症状消失时间和生活质量。结果治疗后,对照组和治疗组的总有效率分别为77.78%、95.56%,两组比较差异有统计学意义(P<0.05)。治疗后,治疗组外阴瘙痒、阴道黏膜充血和阴道分泌物消失时间明显短于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组躯体功能、心理功能、社会功能和物质生活评分均明显升高,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标的升高程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。结论替勃龙片联合双唑泰泡腾片治疗老年性阴道炎具有较好的临床疗效,可缩短临床症状消失时间,改善生活质量,具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Tibolone Tablets combined with Metronidazole Clotrimazole and Chlorhexidine Acetate Effervescent Tablets in treatment of senile vaginitis. Methods Patients （90 cases） with senile vaginitis in Xinyang Fourth People＇s Hospital from January 2016 to July 2016 were enrolled in this study. According to the difference treatment plan, patients were randomly divided into control and treatment groups, and each group had 45 cases. Patients in the control group were placed with Metronidazole Clotrimazole and Chlorhexidine Acetate Effervescent Tablets into vagina deep at bedtime after cleaning the vulva, 1 tablet/time, once daily. Patients in the treatment group were po administered with Tibolone Tablets on the basis of the control group, 1 tablet/time, once daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacies were evaluated, and clinical symptoms disappearance time and quality of life in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 77.78% and 95.56%, respectively, and there was difference between two groups （P 〈 0.05）. After treatment, the clinical symptoms disappearance time of genital itching, vaginal mucosal congestion, and vaginal secretions in the treatment group were shorter than those in the control group, and there was difference between two groups （P 〈 0.05）. After treatment, the scores of physical function, psychological function, social function, and material life in two groups were significantly increased, and the difference was statistically significant in the same group （P 〈 0.05）. And the observational indexes in the treatment group were significantly higher than those in the control group, with significant difference between two groups （P 〈 0.05）. Conclusion Tibolone Tablets combined with Metronidazole Clotrimazole and Chlorhexidine Acetate Effervescent Tablets has clinical curative effect in treatment of senile vaginitis, and shorten clinical symptoms disappearance time, and improve the quality of life, which has a certain clinical application value.