复发/难治性血栓性血小板减少性紫癜的诊治进展

Advance in management of refractory/relapsing thrombotic thrombocytopenic purpura

血栓性血小板减少性紫癜（TTP）是一种发病率低但致死率高的血栓性微血管病（TMA）.过去数年血浆置换使得TTP的预后得到显著改善,但仍有部分患者面临早期复发,另有部分难治性TTP患者面临致死性结局.文章对复发/难治TTP的影响因素和治疗进展进行综述.

Thrombotic thrombocytopenic purpura （TTP） is a kind of thrombotic microangiopathies which has low incidence but highly mortality.The outcome of TTP has been improved significantly since last decade due to the application of plasma exchange,however,early relapse occurs in some patients,and for relapsed/refractory patients the prognosis is still poor.This article reviews the recent progress in treatment and relevant influencing factors of TTP.