复方玄驹胶囊联合五子衍宗丸治疗男性少弱精子症临床研究

Clinical study of Wuzi-Yanzong pill combined with compound Xuanju capsule for the male patients with infertility oligoasthenozoospermia

目的评价复方玄驹胶囊联合五子衍宗丸治疗男性少弱精子症的临床疗效。方法将符合入选标准的136例男性少弱精子症患者采用随机数字表分为2组，每组68例。对照组口服五子衍宗丸、维生素E，研究组往对照组基础上口服复方玄驹胶囊。2组均治疗3个月。观察2组治疗前后精液质r晕=和性激素变化，评价临床疗效。结果研究组总有效率为89．7％（61／68）、对照组为73．5％（50／68），2组比较差异有统计学意义C=5．930，P=0．015）。治疗后，研究组（a＋b）级精子[（68．5±15．5）％比（52．5±15．6）％，t=2．607]、a级精子[（35-3±15．3）％比（26．5±13．4）％，t=-2．688]、精子活动率[（73.3±22．5）％比（56．8±20．5）％，t=2．780]、精子密度[（28．7±15．5）×10^7／ml比（20．5±13．2）×10^7／ml，t=2．612]与精液量[（2．9±1．7）ml比（2.2±1．3）ml，t=2．667]均高于对照组（P〈0．05或P〈O．01）。研究组治疗后睾酮[（816．5±135．6）ng／dl比（768．5±118．5）ng／dl，t=2．728]高于对照组（P〈O．05）。结论五子衍宗丸联合复方玄驹胶囊可有效提高男性少弱精子症患者精子质量，提高疗效。

Objective To assess the clinical effect of Wuzi-Yanzong pill combined with compound Xuanju capsule for treatment of male infertility oligoasthenozoospermia. Methods 136 cases of infertility with less, weak spermatozoa patients who meet the inclusion criteria were divided into two groups using random number table, 68 cases in each group. The control group was treated with Wuzi-Yanzong Pills and Vitamin E orally, and the study group was treated with compound Xuanju capsules on the basis of the control group. Both groups were treated for 3 months. The changes of semen quality and male hormone were observed before and after treatment, and the clinical curative effect was evaluated. Results The total effective rate of the study group was 89.7% （61/68）, the control group was 73.5% （50/68）, there was significant difference between two groups （2,2=5.930, P=0.015）. After treatment, in study group, the sperm of a grade and b grade were （68.5% ± 15.5 % vs. 52.5% ±15.6 %, t=2.607）, the sperm of a grade was （35.3% ~ 15.3% vs. 26.5% ± 13.4%, t=2.688）, sperm motility rate was （73.3% ±22.5% vs. 56.8% ± 20.5%, t=2.780）, sperm density was [（28.7 ±15.5）× 10^7/ml vs. （20.5 ± 13.2）×10^7/ml, t=2.612], and the sperm volume was （2.9± 1.7 ml vs. 2.2 ± 1.3 ml, t=2.667）, higher than those of the control group （P〈0.05 or P〈0.01）. The level of testosterone in study group （816.5 ± 135.6 ng/dl vs. 768.5 ± 118.5 ng/dl, t=2.728）. Conclusions 14/uzi-Yanzong pills combined with compound Xuanju capsule can effectively improve the quality of spermatozoa for patients with oligospermia, and improve the clinical efficacy.