术后复发头颈部鳞癌一线化疗的效果分析

Analysis of the efficacy of first-line chemotherapy in patients with postoperatively recurrent head and neck squamous cell carcinoma

目的比较氟尿嘧啶联合顺铂(PF)和多西他赛联合顺铂和氟尿嘧啶(m TPF)两种化疗方案一线治疗术后复发头颈部鳞癌的效果及不良反应。方法选取2014年3月至2016年9月河南省人民医院收治的术后复发头颈部鳞状细胞癌患者33例,行PF或m TPF方案化疗,3周重复,4个周期后对两组近期疗效和不良反应进行回顾性分析。结果 m TPF组客观缓解率为77.8%,PF组为40.0%,差异有统计学意义(P<0.05)。m TPF组骨髓抑制重于PF组(P<0.05);余不良反应比较,差异无统计学意义(P>0.05)。结论采用m TPF方案一线治疗术后复发头颈部鳞癌较PF方案有更好的近期疗效,且不良反应可耐受。

Objective To compare the clinical efficacy and adverse reactions of Fluorouracil combined with Cisplatin （PF） regimen and Docetaxel combined with Cisplatin and Fluorouracil （mTPF） regimen in first - line treatment of postoperatively re-current head and neck squamous cell carcinomas. Methods 33 patients with postoperatively recurrent head and neck squamous cell carcinoma were selected from March 2014 to September 2016 in Henan Provincial People＇s Hospital, treated with PF or mTPF regimen, repeated every three weeks, and retrospectively analyzed recent clinical efficacy and adverse reactions after 4 cycles. Results The objective response rate was 77. 8% in mTPF group and 40. 0% in PF group, and there was statistically different be- tween the two groups （P 〈 0. 05）. The myelosuppression was more severe in mTPF group than in PF group （ P 〈 0. 05 ）, and other adverse reactions had no statistical difference in two groups （ P 〉 0. 05 ）. Conclusion mTPF regimen had better clinical efficacy than PF regimen in postoperatively recurrent head and neck squamous cell carcinomas and adverse reactions can be tolerated.