射干麻黄汤治疗支气管哮喘的随机对照试验的Meta分析

Clinical Efficacy of Shegan Mahuang Tang for Asthma:A Systematic Review and Meta-analysis

目的:评价射干麻黄汤治疗支气管哮喘随机对照试验的疗效。方法:检索数据库,按纳入标准选择文献,采用Cochrane系统评价员手册进行偏倚风险评估和Jdada评分,评估射干麻黄汤治疗支气管哮喘疗效,同时与西医常规治疗方案对比。结果:共筛选出14篇随机对照试验研究,Jdada评分2~5分,高质量研究1篇(5篇)。经过Meta分析提示射干麻黄汤治疗支气管哮喘的总有效率、FEV1、ACT评分的疗效均优于常规西药对照组,对于PEF、FVC的改善与常规西药组疗效相当。结论:射干麻黄汤治疗支气管哮喘的疗效优于常规西药组,但是大部分文献质量不高,所有文献未随访,了解射干麻黄汤治疗的远期疗效,以后有必要对射干麻黄汤进行更严谨设计的、大样本的双盲随机对照试验。

This study aimed to evaluate the efficacy of Shegan Mahuang Tang in the treatment of asthma. A systematic literature review was conducted on RCTs that compared Shegan Mahuang Tang,versus pharmacotherapy in the treatment of asthma. All included trials were assessed for quality and risk bias and analyzed according to the criteria of the Cochrane Handbook and Jdada score. 14 studies were identified and the Shegan Mahuang Tang group had a positive effect on the total effective rate,a higher score of ACT and the improvement of FEV1 compared with the control group.In the improvement of PEF and FVC,Shegan Mahuang Tang group were equivalent to that of the control group. These results indicate that the efficacy of Shegan Mahuang Tang on asthma is better than that of routine pharmacotherapy.However,the methodology and reporting quality of current studies are generally low.All the literatures did not mention the long term effect. Further studies should include larger sample sizes with a strict design to confirm these findings.