T2DM患者肝脏脂肪含量的危险因素及其与尿酸的相关性研究

Study on risk factors of liver fat content among type 2 diabetic patients and the correlation between liver fat content and uric acid

目的:研究影响2型糖尿病(T2DM)患者肝脏脂肪含量(LFC)的危险因素,并分析LFC与尿酸(UA)的相关性。方法:随机选择538例住院T2DM患者,采用超声定量LFC,并根据LFC水平分为3组:低水平组(LFC≤6.84%)、中等水平组(6.84%<LFC≤19.20%)、高水平组(LFC>19.20%)。测量患者身高、体质量、腰围(WC),并计算体质量指数(BMI),测量收缩压(SBP)及舒张压(DBP),并测定UA、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)等指标;分析LFC与UA的相关性,并利用多元线性逐步回归分析法分析影响LFC的危险因素。结果:随着LFC的增加,各组WC、BMI、DBP、TG、UA值逐步增加,而年龄、糖尿病病程逐步减小(P<0.05);Logistic回归分析显示,年龄、糖尿病病程、BMI、TG、UA为影响LFC的独立危险因素;LFC与WC、BMI、DBP、TG、UA呈正相关性,校正WC、BMI、DBP、TG等指标后,LFC仍与UA显著相关。结论:T2DM患者LFC与UA呈显著正相关性,年龄、糖尿病病程、BMI、TG、UA为影响LFC的危险因素。

Objective： To investigate the risk factors of liver fatcontent （LFC） and the relationship between LFC and uric acid（UA） among type 2 diabetic patients. Methods： A total of 538 type 2 diabetic patients hospitalized were selected randomly, and according to LFC which was measured by ultrasonic quantitative, the subjects were divided into three groups：low level group （LFC≤6.84% ）, middle level group （6.84% 〈 LFC ≤19.20% ） and high level group（ LFC 〉 19.20% ）. Height, weight, waist circumference（WC）, systolic blood pressure（ SBP）, diastolic blood pressure（DBP） of the patients were measured, and body mass index（BMI） was calculated, while UA, total cholesterol （ TC ）, triglycerides （ TG）, high density lipoprotein （ HDL）, low density lipoprotein （LDL） were detected. The correlation between LFC and UA was analyzed and the risk factors of LFC were explored by Multi-factor linear regression analysis. Results： With the increase of LFC, index such as WC, BMI, DBP, TG and UA were gradually increased, while age and course of diabetes disease were gradually decreased （P 〈0.05）. Logistic regression analysis showed that age, course of diabetes disease,BMI,TG and UA were the risk factors of LFC. LFC was positively correlated with WC, BMI, DBP, TG and UA. And after adjusting WC, BMI, DBP, TG, this correlation still significantly existed. Conclusion： LFC is significantly positively correlated with UA among patients with T2DM. Age,course of diabetes disease, BMI, TG and UA are the risk factors of LFC.