中药注射剂对细胞色素P450 2C9酶活性及细胞色素P450 2C9底物的药物代谢影响的研究现状

Research state on effect of traditional Chinese medicine injections on cytochrome P450 2C9 enzyme activity and the metabolism of cytochrome P450 2C9 substrate

临床上应用的中药注射剂有上百种,但其对细胞色素P450 2C9酶活性的研究却很少。中药注射剂对CYP2C9酶的活性不管是抑制或是诱导作用,在应用经CYP2C9代谢的药物时,要重视中药注射剂对其的影响,可能会产生代谢性药物相互作用,为避免药物不良反应发生率增加、药物疗效降低,中药注射剂对CYP2C9酶活性的影响研究值得关注。本文将中药注射剂对CYP2C9酶的活性影响的研究进行了总结和分析,了解中药注射剂对CYP2C9酶活性的影响的研究现状。

There are hundreds of traditional Chinese medicine injections in clinic,but few studies on that effect on the activity of cytochrome P450 2C9 enzymes. Whether traditional Chinese medicine injection inhibit or induce the CYP2C9 enzyme activity,when utilizing medication through CYP2C9 metabolism,we should pay attention to the impact of traditional Chinese medicine injections for they may have metabolic drug interactions. In order to avoid the increase of adverse drug reactions and the decrease of drug efficacy,we should pay our attention to the study on the effect of traditional Chinese medicine injections on CYP2C9 activity. This article summarized and analyzed the effect of traditional Chinese medicine injections on the activity of CYP2C9 enzymes and understood the present situation of its research.