橄榄油、凡士林乳膏及薄荷脑乳膏对老年干皮症患者皮肤屏障功能的影响

Effect of topical olive oil,vaseline cream and menthol ointment on skin barrier function of patients with senile xerosis

目的探讨橄榄油、凡士林乳膏、薄荷脑乳膏3种产品对老年干皮症患者皮肤屏障功能的影响。方法本研究为随机自身对照试验。32例干皮症患者双侧前臂标记4处空白区域,其中3处分别外用橄榄油、凡士林乳膏、薄荷脑乳膏,每日1次持续8周,1处设为空白对照。于第0、2、4、8周时检测皮肤角质层含水量、经表皮水分丢失(TEWL)值和pH值以评价皮肤屏障功能。结果使用8周后,橄榄油组、凡士林乳膏组、薄荷脑乳膏组皮肤的角质层含水量均高于对照组,TEWL和pH值均低于对照组,差异有统计学意义(P<0.05)。使用第0、2、4、8周时,3个实验组间角质层含水量、TEWL值和pH值的差异均无统计学意义。结论外用橄榄油可改善老年干皮症患者皮肤屏障功能,凡士林乳膏、薄荷脑乳膏对于老年干皮症患者皮肤屏障功能也有修复作用。

Objective To evaluate the effect of topical olive oil,vaseline cream and menthol ointment on skin barrier function of patients with senile xerosis.Methods Totally 32 participants with senile xerosis were enrolled in this randomized double-blind self-controlled study for 8weeks.Four black square spaces were marked on bilateral forearms of each volunteer,and three were treated with olive oil,vaseline cream and menthol ointment,respectively,once a day for8 weeks,and the last one was taken as control.Skin barrier function was evaluated at 2,4,and 8 weeks after experiment by measuring the water content of the stratum corneum,transepidermal water loss（TEWL）,and skin pH value.Results Compared with the control group,the water contents of stratum corneum in the olive oil,vaseline cream and menthol ointment groups were significantly increased（P〈0.05）,and the TEWL value and skin pH value were significantly decreased（P〈0.05）at 8 weeks.There were no significant difference in the water content of stratum corneum,TEWL value,or pH value between 3experiment groups.Conclusion Topical olive oil can improve the skin barrier function of patients with senile xerosis,and vaseline cream and menthol ointment also can repair the skin barrier function.