立普妥序贯疗法在择期经皮冠状动脉介入治疗患者中的降脂和抗炎作用观察

Lipid-lowering and anti-inflammatory effects of lipitor sequential therapy on treatment of patients with elective percutaneous coronary intervention

目的探讨立普妥贯治疗对择期经皮冠状动脉介入治疗(PCI)患者的血脂及特异性炎性因子的影响。方法 90例择期PCI患者随机分为序贯组、常规组。用药前及用药后3、30、90、180 d,检测2组治疗前后炎性因子、血脂等指标和不良事件发生率。结果治疗后,2组的TC、LDL-C、MMP-9及MPO均显著降低(P<0.05),且2组MMP-9有显著差异(P<0.05);2组不良反应及不良事件发生率比较无显著差异(P>0.05)。结论序贯治疗和常规治疗均可有效降低血脂,序贯治疗的降脂效果更强。

Objective To explore lipid-lowering and anti-inflammatory effects of lipitor se- quential therapy on treatment of patients with elective percutaneous coronary intervention. Methods Totally 90 patients with PCI were randomly divided into sequential group and routine group. At the time points of before treatment and 3, 30, 90 and 180 days after treatment, inflammatory factors and blood lipid indexes as well as adverse reactions and adverse events were compared between two groups. Results After treatment, levels of TC, LDL-C, MMP-9 and MPO were significantly lower in both groups （ P 〈 0.05 ） , and there was significant difference of MMP-9 between two groups （ P 〈 0.05）. There were no significant differences in adverse reactions and adverse events between two groups （P 〉 0.05 ）. Conclusion Both sequential therapy and conventional therapy can effectively reduce blood lipids, but sequential therapy is better.