缺血性脑血管病患者血脂、同型半胱氨酸水平的变化

Change of serum lipids and homocysteine levels in patients with ischemic cerebrovascular disease

目的分析缺血性脑血管病患者血脂、同型半胱氨酸水平的变化。方法选取缺血性脑血管病(ICVD)患者150例为ICVD组,依据其病情分为短暂脑缺血发作(TIA)组和脑梗死(CI)组,另选择35例健康体检者为对照组。分析4组患者的相关血脂指标及血浆同型半胱氨酸指标。结果 ICVD组、TIA组、CI组与对照组患者的Hcy比较有显著差异(P<0.05)。3组叶酸指标与对照组比较无显著差异(P>0.05)。3组与对照组患者的TC、TG与HDL-C指标比较无显著差异(P>0.05),而LDL-C指标与对照组比较有显著差异(P<0.05)。3组与对照组患者的Apo A1与Apo B对比无显著差异(P>0.05),而Fg指标与对照组对比有显著差异(P<0.05)。结论缺血性脑血管病患者定期检测血清Hcy水平和相关血脂,对预防和干预缺血性脑血管病有较大的诊断价值。

Objective To analyze the change of serum lipids and homocysteine level in patients with ischemie cerebrovascular disease. Methods A total of 150 patients with ischemic cerebro- vascular disease （ICVD） were selected as ICVD group, and the patients were divided into short-term cerebral isehemia （TIA） group and cerebral infarction group （CI） group. Another 35 healthy people were selected as control group. Blood lipid index and plasma homocysteine level were compared among 4 groups. Results There was significant difference of Hcy between ICVD group, TIA group, CI group and control group （ P 〈 0.05 ）. There was no significant difference of folie acid among the four groups （P 〉 0.05）. There were no significant differences in TC, TG and HDL-C between ICVD group, TIA group, C1 group and control group （P 〉 0.05 ） , but there was significant difference in LDL-C （P 〈 0.05）. There were no significant differences in ApoA1 and ApoB between ICVD group, TIA group, CI group and control group （P 〉 0.05 ）, and there was significant difference in Fg （P 〈 0.05 ）. Conclusion Periodic detections of serum Hcy and blood lip index has a great value in prevention and treatment of patients with ischemic cerebrovascular disease.