血清降钙素原和T细胞亚群对脑出血患者感染的预测效果

Predictive effect of serum PCT and T cell subsets on treatment of patients with intra-cerebral hemorrhage

目的探讨血清降钙素原(PCT)和T细胞亚群对脑出血患者感染的预测效果。方法选取脑出血患者80例,依据感染发生情况分为感染组和未感染组,比较2组患者的血清PCT、T细胞亚群。对入组患者的临床资料进行多因素Logistic回归分析,绘制ROC曲线评估血清PCT和T细胞亚群对脑出血患者感染的预测效果。结果感染组患者的血清PCT、CD_8^+显著高于未感染组,CD_3^+、CD_4^+、CD_4^+/CD_8^+显著低于未感染组(P<0.05)。入院时NIHSS评分、血清PCT、CD_3^+、CD_4^+/CD_8^+是影响脑出血患者感染的独立危险因素(P<0.05)。血清PCT、CD_4^+/CD_8^+曲线下面积分别为0.833、0.869,对脑出血患者感染具有良好的预测效果(P<0.05)。结论血清PCT和T细胞亚群是影响脑出血患者感染的独立危险因素。

Objective To investigate the predictive effect of serum PCT and T cell subsets on treatment of patients with cerebral hemorrhage infection. Methods A total of 80 patients with cerebral hemorrhage were divided into infection group and non-infection group. Serum PCT and T cell subsets were compared. Clinical data of patients were analyzed by multivariate Logistic regression analysis, and ROC curve was used to evaluate the effect of PCT and T cell subsets on cerebral hemor- rhage infection. Results Serum PCT and CD8＋ in the infection group were significantly higher than non-infected group, while CD3 ＋ , CD4 ＋ , CD4 ＋/CD8＋ were significantly lower than the non-infection group （P〈0.05）. The NIHSS score on admission, serum PCT, CD3＋, CD4＋/CD8＋ were independent risk factors for infection in patients with intra-cerebral hemorrhage （ P 〈 0.05 ）. The ROC curves of serum PCT, CD4 ＋/CDs ＋ were 0.833, 0.869, which showed good predictive effect for cer- ebral hemorrhage infection （ P 〈 0.05 ）. Conclusion Serum PCT and T cell subsets are independent risk factors for infection in patients with intra-cerebral hemorrhage.