2型糖尿病合并阻塞性睡眠呼吸暂停低通气综合征患者血清脂联素和视黄醇结合蛋白4水平变化及临床意义

Changes of adiponectin and retinol-binding protein 4 in patients with obstructive sleep apnea-hypopnea syndrome and type 2 diabetes mellitus and their clinical significance

目的了解合并阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的2型糖尿病(T2DM)患者的血清脂联素(ADPN)和视黄醇结合蛋白4(RBP4)水平。方法 T2DM合并OSAHS组患者155例,按照睡眠呼吸暂停低通气指数(AHI)再分为轻(62例)、中(53例)、重(40例)3个亚组;单纯OSAHS组35例,单纯T2DM组42例,以同期38例健康体检人群为对照组。采用ELISA法检测血清ADPN和RBP4水平。结果与对照组比较,各组的RBP4水平显著升高,而ADPN水平显著降低(P<0.01);OSAHS合并T2DM各亚组中,RBP4水平随AHI水平的升高而升高,ADPN水平则相反(P<0.01)。结论血清ADPN和RBP4水平与T2DM合并OSAHS患者的严重程度密切相关。

Objective To explore the levels of serum adiponectin （ADPN） and retinol- binding protein 4 （RBP4） in patients with type 2 diabetes mellitus （T2DM） and obstructive sleep ap- nea-hypopnea syndrome （OSAHS）. Methods A total of 155 patients with T2DM and OSAHS were selected and divided into mild group （ n = 62） , moderate group （ n = 53 ） and severe group （ n = 40） according to apnea-hypopnea index （AHI） , 35 OSAHS patients were designed as OSAHS group, 42 T2DM patients were selected as T2DM group, and 38 healthy controls were selected as control group. Serum ADPN and RBP4 levels were detected by ELISA. Results Compared with healthy controls, the serum level of RBP4 significantly increased and the ADPN level significantly decreased in the oth- er three groups （ P 〈 0.01 ）. in subgroups of OSAHS and T2DM group, the level of RBP4 increased with increasing of AHI level, ADPN level is on the contrary （P 〈 0.01 ）. Conclusion The serum levels of ADPN and RBP4 are closely related with the severity of T2DM patients with OSAHS.