腹腔镜下前列腺癌根治术结合内分泌辅助治疗高危前列腺癌的效果

Effect of laparoscopic radical prostatectomy for prostate cancer combined with endocrine adjuvant therapy on the treatment of patients with high-risk prostate cancer

目的探讨腹腔镜下前列腺癌根治术结合内分泌辅助治疗高危前列腺癌的效果。方法选取50例局部晚期高危前列腺癌患者,均行腹腔镜下前列腺癌根治术治疗,根据术后是否进行辅助内分泌治疗(AHT)将其分为观察组及对照组,比较2组手术一般情况及2年生存率。结果 50例患者均成功手术。观察组的2年总体无生化复发率为76%,对照组为52.00%,观察组中进行AHT治疗的所有患者在随访过程中均能够耐受治疗。结论腹腔镜下前列腺癌根治术结合内分泌辅助治疗高危前列腺癌,能够显著提高患者的2年无生化复发率,控制疾病进展。

Objective To explore the effect of laparoscopic radical prostatectomy for prostate cancer combined with endocrine adjuvant therapy on the treatment of patients with high-risk prostate cancer. Methods A total of 50 patients with local advanced high-risk prostate cancer were treated with laparoscopic radical treatment for prostate cancer. According to application of postoperative adju- vant endocrine therapy （AHT）, the patients were divided into the observation group and control group. General surgery condition and 2-year survival rate were compared between two groups. Results All the 50 patients finished operation successfully. The 2-year total biochemical recurrence rate was 76% in observation group, and the control group was 52.00%. The patients received AHT therapy in the observation group were able to tolerate treatment during follow-up. Conclusion Laparoscopic rad- ical prostatectomy for prostate cancer combined with endocrine adjuvant therapy can significantly im- prove 2-year non-biochemical recurrence rate and control the disease progression.