两种巩固治疗方法对复发性外阴阴道假丝酵母菌病的效果比较

Comparison of effect of two consolidation therapies on recurrent vulvovaginal candidiasis

目的比较探讨两种方案对复发性外阴阴道假丝酵母菌病(recurrent vulvovaginal candidiasis,RVVC)的治疗效果。方法将2014年5月至2016年9月成都市锦江区妇幼保健院门诊收治的100例RVVC非妊娠患者分成A、B两组。两组强化治疗均采用口服用药氟康唑150 mg,3 d后重复1次,阴道用药克霉唑栓500 mg,3 d后重复1次。巩固治疗:A组口服氟康唑150 mg/周,连续用6月,B组口服氟康唑150 mg/月,连续用6月。结果两组治疗的有效率均为100%(P>0.05);但A组治愈率为97.96%,高于B组的79.17%,差异有统计学意义(P<0.05)。结论 RVVC巩固治疗中氟康唑150 mg每周用药的效果优于每月用药,值得在临床上选用。

Objective To investigate the effect of two kinds of consolidation therapies on recurrent vulvovaginal candidiasis （RVVC）. Methods From May 2014 to September 2016, 100 cases of RVVC non - pregnant patients admitted to Sichuan Jinxin Women and Children＇s Hospital were divided into group A and group B. Intensive treatment for the two groups was flueonazole 150 mg orally, 1 time/3 days, a total of 2 times and clolrimazole suppositories 500mg vaginally 1 time/3 days, a total of 2 times. Consolidation therapy was fluconazole 150 mg orally, 1 time/a week, a total of 6 months for group A and I time/a month, a total of 6 months for group B. Results Effective rate was 100% for the two groups（ P 〉 0. 05 ）. The cure rate was 97.96% for group A and 79.17% for group B. The difference was statistically significant （ P 〈 0. 05 ）. Conclusion The effect of RVVC consolidation therapy with fluconazole 150mg weekly is better than monthly medication, it is worth in clinical use.