肿瘤坏死因子超家族成员14在哮喘中的研究进展

Research progress of TNFSF14/LIGHT in asthma

肿瘤坏死因子超家族成员14/LIGHT是近年来发现的肿瘤坏死因子超家族新成员,可由T细胞、树突状细胞、NKT等多种细胞产生,主要通过与LTβR(TNFRSF3)和HVEM(TNFRSF14)2种细胞受体结合发挥其生物学活性。现已证实,LIGHT及其信号通路参与了哮喘的病理生理过程,如慢性气道炎症、气道重塑、气道高反应性以及肺纤维化。因此,LIGHT极有可能为哮喘的防治提供新的思路和方法。现就LIGHT在哮喘发病过程中的作用展开综述。

TNFSF14/LIGHT, a new member of the tumor necrosis factor（TNF） super family, is mainly expressed on activated T cells, immature dendritic cells, and NK cells. LIGHT can regulate the function of immune system through binding with herpesvirus entry mediator（HVEM） and lymphotoxin β receptor（LTβR）. Abundant studies revealed that LIGHT and its signal pathway participates in many aspects of pathological processes in asthma,such as chronic airway inflammation, airway remodeling, airway hyper responsiveness, and pulmonary fibrosis.Therefore, LIGHT may provide new ideas and methods for the prevention and treatment of asthma. Here the complicate roles of LIGHT involved in pathological process of asthma are summarized.