摘要
目的研究羽扇豆酮对2型糖尿病大鼠胰岛素抵抗的一般情况、葡萄糖耐量及胰岛素耐量的影响,为羽扇豆酮开发利用提供科学依据。方法通过高糖高脂结合小剂量链脲佐菌素致2型糖尿病大鼠胰岛素抵抗模型,口服给予药物。期间观察大鼠体重、饮水量、进食量、排尿量、精神状态、毛色、活动等一般情况,并测定葡萄糖耐量及胰岛素耐量的水平。结果羽扇豆酮有改善2型糖尿病大鼠胰岛素抵抗一般情况的作用,对糖耐量异常具有改善作用,也能增强机体对胰岛素的敏感性。结论羽扇豆酮在2型糖尿病胰岛素抵抗方面具有一定的开发利用价值。
Objective To research the influence of general situation,glucose tolerance and insulin tolerance for lupenone in insulin resistance of type 2 diabetes rats,which can provide evidence to developing and using of lupenone. Methods The type 2 diabetes rats insulin resistance model was built by high glucose,high fat and low-dose streptozotocin. After oral administration to type 2 diabetes rats,their body weight,water intake,food intake,urine output,mental status,coat color and activities,etc were observed and their level of glucose tolerance and insulin tolerance were measured. Results Lupenone not only had effect of ameliorating general situation and abnormal glucose tolerance of type 2 diabetes rats insulin resistance,but also enhanced the body＇s sensitivity for insulin. Conclusion Lupenone has a development and utilization value in terms of insulin resistance in type 2 diabetes.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2017年第5期1035-1037,共3页
Lishizhen Medicine and Materia Medica Research
基金
国家自然科学基金(No.81260686)
贵州省优秀青年科技人才培养对象专项资金(No.黔科合人字[2013]46号)
贵州省中药现代化公关计划项目(No.黔科合ZY[2012]3016号)
关键词
羽扇豆酮
胰岛素抵抗
一般情况
糖耐量
胰岛素耐量
Lupenone
Insulin resistance
General situation
Glucose tolerance
Insulin tolerance
