基于关联规则和复杂系统熵聚类的股骨颈骨折用药规律研究

Analysis on Medication Rule in Herbal Prescriptions for Femoral Neck Fracture

目的:分析股骨颈骨折中药处方的用药规律。方法:搜集中国知网、维普、万方、中国生物医学文献数据库2011—2016年治疗股骨颈骨折的中药处方,采用TCMISS中医传承辅助平台软件,对处方中各药物的使用频次、四气五味归经、归类以及药物之间的关联规则等进行分析和提取。结果:对323个中药处方进行分析,使用频率较高的中药有当归、红花、川芎、熟地黄、桃仁、续断、骨碎补、牛膝、赤芍、白芍等;药物的四气分布主要为温、平、凉,五味分布主要为苦、甘、辛;归经分布主要为肝、脾、肾、心;药物归类分布主要为伞形科、毛茛科、菊科。当归、熟地黄、白芍、川芎、红花、桃仁等均为临床治疗股骨颈骨折最常用的中药。结论:中药治疗股骨颈骨折以活血化瘀为主要治法,常用处方为桃红四物汤。

Objective： To analyze the medication rule in herbal prescriptions for femoral neck fracture. Methods： Herbal prescriptions for femoral neck fracture were searched from Chinese National Knowledge Infrastructure, VIP database, Wanfang database and Chinese Biomedical Database, from 2011 to 2016. We used Chinese medicine inheritance support system （TCMISS） to analyze the frequency, four natures, five flavors, meridian entry, plant classification of drugs, and the association rules between drugs. Results： Based on the analysis of 323 herbal prescriptions, herbs used with high frequency were Danggui （Radix Angelicac Sincnsis）, Honghua （Flos Carthami）, Chuanxiong （Rhizoma of Chuanxiong）, Shudihuang （RadixRehmanniae Praeparata）, Taoren （Semen Persicae）, Xuduan （Radix Dipsaci）, Gusuibu （Rhizoma Drynariae）, Niuxi （Radix Achyranthis Bidentatae）, Chishao （Radix Paeoniae Rubra）, Baishao （Radix Paeoniae Alba）, et al. Four natures of drugs were mainly consisting of warmth, neutral and coolness. Five flavors of drugs were mainly consisting of bitter, sweet and pungent. Meridian entries were mainly consisting of liver, spleen, kidney and heart. Plant classification of drugs was mainly consisting of Apiaceae, Ranunculaceae and Asteraceae. Danggui （Radix Angelicae Sinensis）, Shudihuang （Radix Rehmanniae Praeparata）, Baishao （Radix Paeoniae Alba）, Chuanxiong （Rhizoma of Chuanxiong）, Honghua （Flos Carthami） and Taoren （Semen Persicae） were the most commonly used traditional Chinese Medicine for femoral neck fracture. Conclusion： The main principles of treatment for femoral neck fracture is promoting blood circulation for removing blood stasis, the most commonly used traditional Chinese medicine prescription was Taohong Siwu Decoction （桃红四物汤）.