莫西沙星与左氧氟沙星治疗老年耐药性肺结核对比观察

A comparative observation on the efficiency of moxifloxacin and levofloxacin in the treatment of elderly drug-resistant tuberculosis

目的对比观察莫西沙星与左氧氟沙星对老年耐药性肺结核的治疗效果。方法选取2014年12月至2015年6月在郑州市第六人民医院治疗的耐药性肺结核老年患者60例,随机分为对照组与观察组,各30例。对照组采用VDL2E方法进行治疗,观察组采用MDL2E方法进行治疗。对比观察两组患者痰菌转阴情况、治疗效果以及不良反应发生情况。结果治疗1、2、4、8个月后,观察组患者痰菌转阴率分别为60.0%、73.33%、83.33%、93.33%,均显著高于对照组的26.67%、40.0%、53.33%、93.33%,差异有统计学意义(P<0.05);观察组治疗总有效率为90.0%,显著高于对照组的50.0%,差异有统计学意义(P<0.05);治疗后,观察组各项不良反应发生率均显著低于对照组,差异有统计学意义(P<0.05)。结论莫西沙星治疗老年耐药性肺结核效果显著,能积极帮助患者的痰菌转阴,且不良反应发生率低,值得临床推广。

Objective To compare the efficiency of moxifloxacin and levofloxacin in the treatment of elderly drug - resistant tuberculosis. Methods Sixty patients who treated drug - resistant tuberculosis in the Sixth People＇sHospital of Zhengzhou from December 2014 to June 2015 were randomly divided into control group and observation group, 30 cases of the control group were used VDL2E methods, 30 cases of the observation group were used MDL2E methods. The sputum negative conversion rate, treat- ment effect, adverse reactions were compared. Results After treatment of 1,2,4, 8 months of treatment, the sputum negative conversion rate in the observation group were 60. 0%, 73.33%, 83. 33%, 93. 33%, 26. 67%, which were significantly higher than the 40. 0%, 53.33%, 93.33% in the control group （ P 〈 0. 05 ） ; The total effective rate in the observation group was 90.0% , which was significantly higher than the 50.0% in the control group（P 〈 0. 05 ） ; The adverse reactions in the observation group after treatment was significantly lower than the control group （P 〈 0. 05）. Conehtsion Moxixfloxacin in the treatment of elderly drug-resistant tuberculosis has a significant effect. It can actively help patient sputum become negative and be lower incidence of adverse reactions. It is worthy of promotion.