Smad3蛋白在肝细胞癌中的作用

Research progress on Smad3 protein in hepatoceUular carcinoma

】Smad3是转化生长因子β（TGF—β）信号通路中重要的转运蛋白。它负责把TGF-β信号从细胞膜表面转运入细胞核，使TGF-β信号能与核内相关因子结合，调控靶基因的表达。Smad3表达水平及功能状态异常将导致信号转导过程异常，涉及细胞的生长、增殖、发育、分化、迁移、凋亡等基本环节。本文以肝细胞癌和癌旁差异表达的Smad3基因为核心的作用。从Smad3上游信号源、Smad3自身装配成熟、Smad3下游效应三个部分阐述当前Smad3在肝细胞癌中的研究进展，旨在为Smad3在肝细胞疾病中的后续研究提供参考。

Smad3 is a major transporter in the transforming growth factor β （TGF-β） signaling pathway. It is in charge of the transfer of TGF-β signal from the surface of the cell membrane into the nucleus. The TGF-β signal can be bound to the target gene in the nucleus and regulate its expression. Abnormalities in Smad3 expression level and functional status will lead to abnormal signal transduetion, involving cell growth, proliferation, development, differentiation, migration, apoptosis and other basic life activities. This review focused on the differential expression of Smad3 in hepatoeellular carcinoma （ HCC ） and the adjacent tissue. The character of Smad3 in HCC is outlined in three parts： Smad3 upstream signaling source, Smad3 self-assembly maturation and Smad3 downstream effects, which may provide a summary and reference for the follow-up study on Smad3.