茵栀黄颗粒治疗新生儿黄疸的临床效果观察

Observing the clinical effects of therapy to neonatal jaundice by Yinzhihuang particles

目的 观察茵栀黄颗粒治疗新生儿黄疸的临床效果.方法 选取浙江省杭州市萧山区第一人民医院儿科2015年7月-2016年12月收治疗的确诊为黄疸的新生儿72例,按随机数字表法分为观察组和对照组各36例,对照组患儿给予蓝光照射治疗,观察组患儿在对照组基础上给予茵栀黄颗粒治疗,随访并记录2组患儿血清C反应蛋白（CPR）、总胆红素（TBIL）、γ-谷丙氨酰基转移酶（γ-GT）、碱性磷酸酶（AKP）以及游离脂肪酸（FFA）水平和不良反应发生率情况,采用统计学方法对数据进行分析.结果 ①观察组在治疗后CRP、TBIL、γ-GT值均优于对照组,且差异均有显著性（P〈0.05）.②观察组在治疗后AKP、FFA值均优于对照组,且差异均有显著性（P〈0.05）.③观察组在治疗过程中皮疹、腹泻发生率分别为（0.00%、2.78%）,均低于对照组（11.11%、16.67%）,且差异均有显著性（P〈0.05）.结论 茵栀黄颗粒治疗新生儿黄疸效果良好.

Objective To observe the clinical effects of therapy to neonatal jaundice by Yinzhihuang particles.Methods72 cases from July 2015 to December 2016, were randomly divided into two groups and made all 36 cases in the control group, children in the control group given blue light therapy observation group were treated in the control group on the basis of Yinzhihuang particle therapy, follow-up and record two serum C-reactive protein （CRP）, total bilirubin （TBIL）, γ-alanine amino acyltransferase （γ-GT）, alkaline phosphatase （AKP） and free fatty acid （FFA） levels and incidence of adverse reactions, the use ofstatistical methods for data analysis.Results① observation group after treatment CRP,TBIL, γ-GT values were better than the control group, and the difference was significant （P〈0.05）.② observation group in the AKP, FFA values after treatment than the control group, and the difference was significant （P〈0.05）.③ observation group rash during treatment, the incidence of diarrhea were （0.00%, 2.78%）, were lower than the control group （11.11%, 16.67%）, and the difference was significant （P〈0.05）.ConclusionYinzhihuang particle treatment of neonatal jaundice effect is good, worthy of further research and application.