复方丹参注射液联合尼莫地平治疗蛛网膜下隙出血的临床疗效分析

The clinical efficacy of treatment of subarachnoid hemorrhage with Danshen solution combine nimodipine

目的 观察研究复方丹参注射液联合尼莫地平治疗蛛网膜下隙出血的临床疗效.方法 研究对象来自首都医科大学附属北京朝阳医院神经外科收诊的80例蛛网膜下隙出血患者,收治时间为2014年1月-2015年2月,随机原则分为2组,2组均给予尼莫地平治疗,观察组另外加用复方丹参注射液,记录并分析治疗前后2组患者脑脊液 S-100B 蛋白变化状况、疾病治疗状况及2组患者并发症发生率.结果 ①治疗5d、7d、14d后观察组患者S-100B蛋白分别（0.788±0.14）μg/L、（0.625±0.15）μg/L、（0.501±0.13）μg/L,均优于对照组（0.957±0.16）μg/L、（0.823±0.17）μg/L、（0.711±0.12）μg/L,且差异均有统计学意义（P〈0.05）;②治疗后观察组总有效率达90.0%,高于对照组67.5%,且差异有统计学意义（P〈0.05）;③观察组再出血、脑缺血、脑积水等并发症与对照组相当,2者差异无统计学意义;④观察组治疗后NO值为（48.61±8.18）μmol/L,优于对照组（40.25±9.37）μmol/L,且差异有统计学意义（P〈0.05）.结论 复方丹参液可调节蛛网膜下隙出血患者的相关因子,从而提高治疗效果.

Objective To observe the clinical efficacy of treatment of subarachnoid hemorrhage with Danshen solution combine nimodipine.Methods80 cases diagnosis with subarachnoid hemorrhage from January 2014 to February 2015, were randomly divided into observation group and control group 40cases, observation group were plus conventional therapy Danshen solution treatment, the control group were given nimodipine only conventional treatment, recorded and analyzed before and after treatment S-100B protein in cerebrospinal fluid situation, status and treatment of disease incidence of complications in patients with two groups of patients.ResultsTreatment 5d, 7d, 14d after S-100B protein were observed in patients （0.788±0.014）μg/L,（0.625±0.15）μg/L,（0.501±0.13）μg/L, were better than the control group （0.957±0.16）μg/L,（0.823±0.17）μg/L,（0.711±0.12）μg/L, and the differences were statistically significant （P〈0.05）.Treatment observation group total effective rate of 90.0%, higher than 67.5%, and the difference was significant （P〈0.05）.The treatment group rebleeding, cerebral ischemia, hydrocephalus and other complications with the control group fairly, the difference was not significant.ConclusionIt is effective for the treatment of subarachnoid hemorrhage withdanshen solution combine nimodipine, can significantly improve the cure rate in patients with subarachnoid hemorrhage, reducing mortality.It is worthy of further research and applications.