前列地尔联合贝那普利在糖尿病患者中的应用及对血糖波动的影响研究

Study on the application of alprostadil and benazepril in patients with diabetes and the effect on blood glucose fluctuation

目的 分析前列地尔联合贝那普利治疗糖尿病的效果及对患者血糖波动的影响.方法 将80例糖尿病患者随机分为对照组与观察组,各40例,对照组单用贝那普利治疗,观察组加用前列地尔治疗,比较2组治疗效果及血糖、血脂、肾功能水平的变化,记录不良反应发生率.结果 ①观察组治疗总有效率高于对照组（P〈0.05）;②治疗后,2组空腹血糖（FPG）、餐后2h血糖（2hPG）、糖化血红蛋白（HbA1c）均降低至正常范围,但观察组FPG、2hPG波动差值低于对照组（P〈0.05）;③治疗4周,2组总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）均降低,高密度脂蛋白胆固醇（HDL-C）上升,与同组治疗前对比差异有统计学意义（P〈0.05）,但组间对比差异无统计学意义;④观察组治疗后肾功能指标改善情况优于对照组（P〈0.05）,且2组不良反应发生率对比差异无统计学意义.结论 采用前列地尔联合贝那普利治疗糖尿病可减少患者血糖波动,改善其肾功能,降低糖尿病肾病发病风险.

Objective To analyze the effects of alprostadil combined with benazepril in the treatment of diabetes and the effect on blood glucose fluctuation.MethodsEighty cases with diabetes were randomly divided into the control group and the observation group with 40 cases in each group.The control group was treated with benazepril while the observation group was additionally treated with alprostadil.The treatment effects, the changes of blood glucose, blood lipids and renal function were compared between the two groups, and the incidence of adverse reactions was recorded.ResultsThe total effective rate in the observation group was higher than that in the control group （P〈0.05）.After treatment, the fasting plasma glucose （FPG）, postprandial 2h plasma glucose （2hPG） and glycosylated hemoglobin （HbA1c） were reduced to the normal level but the volatility differences of FPG and 2hPG in the observation group were lower than those in the control group （P〈0.05）.After 4 weeks of treatment, the total cholesterol （TC）, triglyceride （TG） and low-density lipoprotein cholesterol （LDL-C） decreased while high-density lipoprotein cholesterol （HDL-C） increased （P〈0.05） but the differences between the two groups showed no statistical significance.After treatment, the improvement of renal function indexes in the observation group was better than that in the control group （P〈0.05）, and the incidence of adverse reactions showed no significant difference between the two groups.ConclusionThe application of alprostadil combined with benazepril in the treatment of diabetes can reduce blood glucose fluctuation, improve renal function, and reduce the risk of diabetic nephropathy.