CT引导下组织间植入125I粒子联合替吉奥治疗老年胰腺癌疗效分析

CT analysis of curative effect of pancreatic cancer in the elderly 125I implantation combined with S-1 treatment among organizations

目的 研究分析在CT引导下组织间植入125I粒子联合替吉奥治疗老年胰腺癌的治疗效果,评价其实际的临床价值.方法 选取浦江县人民医院放射科于2013年1月-2016年12月收治的60例老年胰腺癌患者作为本次研究过程中的研究对象,随机分为对照组和实验组,各30例.对照组患者替吉奥治疗,实验组患者进行植入125I粒子联合替吉奥治疗.比较分析对照组和实验组患者的治疗效果以及毒性反应等情况.结果 经过不同方式的治疗后,实验组30例患者中,9例患者为无效,总有效例数为21例,治疗有效率为70.0%.对照组30例患者中,19例患者为无效,总有效例数为11例,治疗有效率为36.7%.由此可得,实验组患者的治疗有效率显著高于对照组患者,差异具有统计学意义（P〈0.05）.实验组患者的疾病控制率为90.0%,临床收益率为50.0%,对照组患者的疾病控制率60.0%,临床收益率为23.3%.可得,实验组患者的疾病控制率和临床收益率显著高于对照组,差异具有统计学意义（P〈0.05）.实验组与对照组患者毒性反应的发生情况并无显著差异,不具有统计学意义.结论 CT引导下组织间植入125I粒子联合替吉奥在治疗老年胰腺癌中的应用能够在很大程度上提高治疗有效率,帮助缓解患者痛苦,具有进一步临床推广和应用的意义.

Objective To study the guided interstitial implantation of125I seeds combined with S-1 in the treatment of elderly patients with pancreatic cancer treatment in CT, to evaluate the clinical value of the actual.Methods60 cases of elderly patients with pancreatic cancer in Pujiang People＆#39;s Hospital from January 2013 to December 2016 were selected as the research object in this study.They were randomly divided into two groups, the control group and the experimental group, each with a total of 30 cases.The control group of patients with S-1 in the treatment.The experimental group with,125I implantation combined with S-1 treatment.Comparative analysis of the control group and the experimental group of patients with treatment effect and toxicity.ResultsAfter different treatment, 30 patients in the experimental group, 9 patients were invalid, the total effective number of cases was 21 cases, the effective rate was 70%.The control group of 30 patients, 19 patients were invalid, the total effective number of cases was 11 cases, the effective rate was 36.7%.Therefore, the effective rate of the experimental group was significantly higher than that of the control group, with statistical difference （P〈0.05）.The disease control rate of the experimental group was 90%, the clinical benefit rate was 50%, the control rate of the patients in the control group was 60%, and the clinical benefit rate was about 23.3%,.The control rate of patientsand the clinical benefit rate of the experimental group was significantly higher than that of the control group, with statistical difference （P〈0.05）.There was no significant difference between the experimental group and the control group.ConclusionCT guided interstitial implantation of125I seeds combined with S-1 in the treatment of elderly patients with pancreatic cancer can improve the treatment efficiency to a great extent, to help alleviate the suffering of patients, with further clinical promotion and application significance.