止嗽化痰胶囊联合左氧氟沙星治疗慢性支气管炎急性发作的临床观察

Clinical observation of Zhisou Huatan capsules combined with levofloxacin in the treatment of acute exacerbations of chronic bronchitis

目的 探讨止嗽化痰胶囊联合左氧氟沙星对慢性支气管炎急性发作患者的治疗效果.方法 回顾性分析2015年2月-2016年12月在金华市中心医院接受治疗的慢性支气管炎急性发作患者的临床资料,根据其治疗方式分为左氧氟沙星治疗组和止嗽化痰胶囊联合左氧氟沙星治疗组.治疗4周后,观察2组治疗前后症状积分、肺功能、炎症细胞因子水平和副作用发生情况.结果 2组患者治疗前症状积分无差别,治疗后,联合治疗组咳嗽、咳痰和肺部听诊积分均低于左氧氟沙星组（t=9.039、3.574、7.962,P〈0.001）;2组治疗前肺功能指标无差别,治疗后,联合治疗组FVC、FEV1、FEV1/FVC、MMEF和PEF水平高于左氧氟沙星组;2组治疗前血清炎症细胞因子水平无差别,治疗后,联合治疗组IL-8、hs-CRP和TNF-α水平低于左氧氟沙星组（t=25.301、3.615、5.733,P〈0.001）;治疗4周后,血、尿检查结果提示2组患者均未出肝肾功能异常,具有较好的安全性.结论 止嗽化痰胶囊联合左氧氟沙星对慢性支气管炎急性发作有较好的治疗效果,可明显改善患者的症状和肺功能,具有临床应用价值.

Objective To investigate zhisouhuatan capsule combined with levofloxacin in the treatment of patients with acute exacerbation of chronic bronchitis.MethodsRetrospective analysis was used to analysis the clinical data of patients with acute exacerbations of chronic bronchitis treated in our hospital from February 2015 to December 2016,according to the treatment methods, which were divided into levofloxacin treatment group and zhisouhuatan capsule combined with levofloxacin in the treatment group.After 4 weeks treatment, the symptom scores, lung function, inflammatory cytokine levels and side effects of the two groups were observed before and after treatment.ResultsThe symptom score of the two groups of patients before treatment had no difference, after treatment, the cough, expectoration and lung auscultation score of combined treatment group were lower than levofloxacin group （t=9.039, 3.574, 7.962, P〈0.001）;There was no difference between the two groups before treatment.After treatment, the levels of FEV1, FEV1/FVC, MMEF, PEF and FVC in the combined treatment group were higher than that in the levofloxacin group;There was no difference in serum inflammatory cytokine levels between the two groups before treatment.After treatment, the levels of IL-8, hs-CRP and TNF-in the combined treatment group were lower than that in the levofloxacin group （t=25.301, 3.615, 5.733, P〈0.001）;After 4 weeks of treatment, the blood and urine test results showed that the two groups of patients were not out of liver and kidney dysfunction, with good safety.ConclusionZhisouhuatan capsule combined with levofloxacin on acute exacerbation of chronic bronchitis has good curative effect, can significantly improve symptoms and pulmonary function of patients, with clinical application value.