康妇消炎栓联合头孢曲松钠治疗慢性盆腔炎的效果观察

Observation on the effect of Kangfu Xiaoyan suppository combined with ceftriaxone sodium in treating chronic pelvic inflammatory disease

目的 观察康妇消炎栓联合头孢曲松钠治疗慢性盆腔炎的临床疗效.方法 选取2015年6月-2016年8月湖州市妇幼保健院妇产科收治的慢性盆腔炎患者84例,按随机数字表法分为观察组及对照组各42例,对照组患者单独应用头孢曲松钠治疗,观察组在对照组基础上加用康妇消炎栓治疗,记录并分析治疗后2组患者肿瘤坏死因子 α（TNF-α）、转换生长因子β1（TGF-β1）、白细胞介素8、1β（IL-8、IL-1β）以及临床症状评分的变化.结果 ①治疗2周后观察组患者总有效率达92.86%,明显高于对照组76.19%,且差异有统计学意义（P〈0.05）.②观察组患者治疗后TNF-α、TGF-β1值[（0.80±0.23）μg/L、（12.43±1.98）μg/mL]均优于对照组[（1.81±0.35）μg/L、（19.01±2.24）μg/mL],差异均具有统计学意义（P〈0.05）;③观察组治疗后下腹疼痛、白带症状评分[（1.57±0.11）、（1.45±0.15）分]均低于对照组[（2.05±0.17）、（2.16±0.20）分],差异均具有统计学意义（P〈0.05）.结论 康妇消炎栓联合头孢曲松钠治疗慢性盆腔炎的疗效肯定、确切,与单独应用头孢曲松钠治疗相比无明显不良反应,能有效改善患者慢性盆腔炎症状,值得临床进一步研究和应用.

Objective To observe the clinical efficacy of treatment of chronic pelvic inflammatory disease with Kangfu Xiaoyan suppository combined ceftriaxone.Methods84 cases of chronic pelvic inflammatory disease in our hospital from June 2015 to August 2016 were randomly divided into observation group and control group, with 42 cases in each group.The control group were treated with ceftriaxone sodium alone,on the basis of the control group, the observation group was treated with Kangfu Xiaoyan suppository.After treatment, the changes tumor necrosis factor-α （TNF-α）, transforming growth factor β1 （TGF-β1）, interleukin 8,1β （IL-8, IL-1β） and clinical symptom score in the two groups were recorded and analyzed.Results①After two weeks of treatment, the total effective rate of observation group was 92.86%, significantly higher than that of the control group（76.19%）, and the difference was statistically significant （P〈0.05）.②After treatment,the levels of TNF-α, TGF-β1 in the observation group[（0.80±0.23）μg/L, （12.43±1.98）μg/mL） were better than the control group[（1.81±0.35）μg/L,（19.01±2.24）μg/mL], and the differences were statistically significant （P〈0.05）;③After treatment,the abdominal pain, vaginal symptom score of observation group[（1.57±0.11）,（1.45±0.15） points] were lower than the control group[（2.05±0.17）,（2.16±0.20） points], and the differences were statistically significant （P〈0.05）.ConclusionKangfute Xiaoyan Suppository combined with ceftriaxone sodium in the treatment of chronic pelvic inflammatory disease, curative effect is exact, compared with the single application of ceftriaxone sodium in the treatment without obvious adverse reactions, can effectively improve the symptoms of patients with chronic pelvic inflammatory disease, it is worthy of further research and application.