2012～2016年我院抗肝病药物的调查研究分析

Investigation and analysis of anti liver disease drugs in our hospital during 2012 to 2016

目的 分析抗乙肝病毒药物的应用情况,为临床合理用药、提高肝病治疗效果提供参考.方法 利用医院管理系统,收集上海市复旦大学附属中山医院2012-2016年各种类型抗肝病药物的应用情况,包括药物剂型、药品名称、规格、用药数量、用药金额等,利用用药数量、用药金额、用药频度（DDDs）、日用药费用（DDDc）等指标进行排序及分析.结果 本院抗肝病药物的总用药数量和用药金额呈现逐渐升高的趋势,用药金额年增长率也呈现出逐渐升高的趋势,其中2015年度用药金额增长比率最高,为41.56%.每年保肝药物在各种抗肝病药物中所占的比例均为首位,保肝药物中用药金额及占比最大的为还原性谷胱甘肽,抗病毒药物中用药金额及占比最大的为恩替卡韦.结论 本院抗肝病药物的应用呈现出逐年增长的趋势,用药金额的年增长率较高,提示本省肝病的发病率呈现出升高的趋势.同时保肝类药物占比较大说明本院存在该类药物滥用的现象,应引起临床医生的重视.在促进抗肝病药物合理应用上,临床医师和药师应共同做好药品的评估情况,以达到有效、合理、安全且经济的药物应用目的.

Objective To analyze the application situation of the anti HBV drugs, and provide reference for clinical rational use of drugs and improve the therapeutic effect of liver disease.MethodsBy using the method of hospital management system, the application situation from 2012 to 2016 in our hospital of various types of anti liver disease drugs, including drug name, dosage forms.The specifications, the number of drug, drug cost, drug use quantity, the amount of medication, medication frequency （DDDs）, daily drug cost （DDDc） and other indicators were sorted and analyzed.ResultsThe total amount and drug therapy of anti liver disease drug in our hospital showed increasing trend,the annual growth rate of the amount of medication was also showing a rising trend, the 2015 annual growth in the amount of medication for the highest rate, 41.56%.The annual hepatoprotective drugs in various anti proportion are the first in liver disease drug, liver drugs accounted for the largest amount of drugs and the reduced glutathione, the amount of drugs and antiviral drugs in the largest proportion of entecavir.ConclusionThe application of Anti Sense drugs showing a growth trend year by year, the amount of medication of the annual growth rate is higher, suggesting that the incidence rate of liver disease in our province had a rising trend.At the same time, hepatoprotective drugs accounted for relatively large of the existence medicine The phenomenon of substance abuse, clinicians should pay attention to.In the promotion of rational use of anti hepatitis drugs, clinicians and pharmacists should jointly do a good job of drug evaluation, has achieved the effective, reasonable application of drug safety and economic purposes.