骨肉瘤相关分子机制研究进展

Research progress in molecular mechanism of osteosarcoma

骨肉瘤是临床常见的骨科恶性肿瘤之一,其侵袭力强,可早期转移,预后差。近年来,对于骨肉瘤的相关信号通路及分子机制研究愈发收到学者的重视,且对于信号通路、分子机制的研究也为骨肉瘤的治疗提供了更多的可能。本文主要从细胞信号通路,抑癌基因、癌基因表达失衡,成骨细胞分化缺陷三部分介绍骨肉瘤相关分子机制研究进展。

Osteosarcoma（OS） is one of the common malignant tumors in Department of Orthopedics. It has strong invasion ability, and early metastasis and poor prognosis. In recent years, studies regarding the signaling pathways and molecular mechanisms of osteosarcoma have received more and more attention among the scholars, which also provides more possibilities for the treatment of osteosarcoma. This article introduces the osteosarcoma related molecular mechanisms mainly from the cell signaling pathway, tumor suppressor gene and oncogene expression imbalance, and osteogenic differentiation defect.