心肌损伤标志物危急值的验证

Verification of Myocardial Injury Markers' Critical Values

目的验证心肌损伤标志物在急性心肌梗死(acute myocardial infarction,AMI)中的变化趋势,及实验室危急值设置与疾病发展的符合性。方法选取就诊于我院的125例AMI患者及125例无AMI患者,在发病时间段测定肌钙蛋白Ⅰ(cTnⅠ)、肌红蛋白(MYO)、肌酸激酶同工酶(CK-MB)的水平。结果 cTnⅠ、MYO、CK-MB分别于发病后5~6h、3~5h、3~5h开始升高,峰值的均值分别可达8.4ng/mL、2685.1ng/mL、43.9ng/mL,急性升高初期均值分别为0.8ng/mL、298.5ng/mL、15.9ng/mL。结论 AMI急性发作时血清学指标CTnI、MYO、CK-MB明显升高,于发病早期诊断意义更大,各项指标的血清学变化趋势符合疾病的发展趋势,我院实验室对这三项指标的危急值设定合理,能在AMI诊断和治疗中起到预警作用。

Objective To validate myocardial injury markers′ trend in acute myocardial infarction, and the conformity between critical values and disease development.Methods 125 patients and 125 healthy contrl were recruited in the study.Plasma troponin I （cTnI）, myoglobin （MYO）,and creatine kinase-MB （CK-MB） at onset time were tested.Results Level of cTnI, MYO and CK-MB increased at 5-6h, 3-5h and 3-5h respectively, with maximum of 8.4ng/mL, 2685.1ng/mL and 43.9ng/mL.The starting value were 0.8ng/mL, 298.5ng/mL and 1.9ng/mL respectively.Conclusion Myocardial injury markers elevated significantly in AMI onset time and the critical values in our laboratory is required.