变应性鼻炎鼻黏膜上皮细胞免疫活性研究进展

Immunocompetence of nasal epithelial cells in allergic rhinitis

鼻黏膜上皮细胞构成的物理和化学屏障是呼吸道接触外源性微生物、变应原和环境污染物等的第一道防线。除理化屏障功能,上皮细胞在变应性鼻炎发病机制中的免疫调控作用受到越来越多的重视。上皮细胞对天然免疫和获得性免疫均具有重要的免疫调控功能,这种免疫调控功能的实现依赖于功能性细胞因子的表达及上皮细胞与下游免疫细胞的相互信息传递。现就鼻黏膜上皮细胞与变应原及其他免疫细胞之间的信息传递做一简要梳理。

Although much is known about the imbalance of Th1/Th2 in allergic rhinitis（ AR）,the role of nasal epithelial cells as the first line of mucosal defense against inhaled pathogens remains undefined,despite the growing concern surrounding it. We nowrealize that epithelial cells recognize allergens through expression of pattern-recognition receptors and then mount the innate and adaptive immune responses. Therefore,epithelial cells are crucial in determining the outcome of allergen inhalation in AR. Here,we will reviewthe literature on immunocompetence of nasal epithelial cells in AR.