替吉奥单药联合西药强调放疗同步治疗老年晚期非小细胞肺癌的效果

Clinical efficacy of Gimeracil and Oteracil Porassium Capsules combined with Cisplatin concomitant radiotherapy and radiotherapy treatment for elderly patients with advanced non-small cell lung cancer

目的观察替吉奥联合顺铂放疗同步与单纯放疗法治疗老年晚期非小细胞肺癌的的临床效果。方法选择2012年3月~2014年3月于南京大学医学院附属鼓楼医院接受诊治的38例老年晚期非小细胞肺癌患者,根据完全随机化分组法,分为观察组(n=19)和对照组(n=19)。观察组采用替吉奥联合顺铂放疗同步治疗,对照组采用单纯放疗法治疗。两组均以等同于化疗时间的3个周期为观察周期。对比分析两组治疗总有效率、毒副作用发生率以及1年生存率。结果观察组总有效率显著高于对照组(P<0.05);观察组与对照组放射性肺炎及放射性食管炎毒副作用发生率比较差异无统计学意义(P>0.05);观察组白细胞减少、血小板减少、恶心呕吐及腹泻发生率显著高于对照组(P<0.05);观察组1年生存率显著高于对照组(P<0.05)。结论替吉奥联合顺铂放疗同步比单纯放疗法治疗老年晚期非小细胞肺癌的临床效果显著,可明显提高患者1年生存率。

Objective To observe the clinical efficacy of Gimeracil and Oteracil Porassium Capsules combined with Cisplatin concomitant radiotherapy and radiotherapy treatment for elderly patients with advanced non-small cell lung cancer.Methods 38 cases of elderly patients with advanced non-small cell lung cancer treated in Nanjing Drum Tower Hospital the Affiliated Hospital of Nanjing University Medical School were selected from March 2012 to March 2014.They were randomly divided into the observation group（n=19） and the control group（n=19） according to completely randomized grouping method.Patients of the observation group were treated with Gimeracil and Oteracil Porassium Capsules combined with medicine concomitant radiotherapy, and the patients of the control group were treated with radiotherapy only.The two groups both received 3 cycles of chemotherapy.The total effective rate, toxicity and 1-year survival rate of the two groups were compared.Results The total effective rate was significantly higher in the observation group than that in the control gorup（P〈 0.05）.The incidence of radiation pneumonitis and esophagitis between the two groups had no significant differences（P 〉0.05）.The incidence of leucopenia reduction, blood platelet reduction,nausea, vomiting and diarrhea were significantly higher in the observation group than those in the control gorup（P 〈0.05）.1-year survival rate was significantly higher in the observation group than that in the control gorup（P〈 0.05）.Conclusion Compared with the treatment of radiotherapy only, the clinical efficacy of Gimeracil and Oteracil Porassium Capsules combined with Cisplatin concomitant radiotherapy is significant, it can significantly improve the survival rate.