血清磷脂酶A2水平对阿奇霉素序贯疗法治疗儿童支原体肺炎效果的影响

Effect of serum phospholipase A2 levels on Azithromycin sequential therapy for children with Mycoplasma pneumonia

目的探讨血清磷脂酶A2(PLA2)水平对阿奇霉素序贯疗法治疗儿童支原体肺炎效果的影响。方法选取2015年6月~2016年12月崇州市人民医院儿科诊治的84例支原体肺炎患儿为研究对象,测定血清PLA2的变化水平,以PLA2中位数为分界值,将患儿分为高PLA2组和低PLA2组,每组各42例。比较阿奇霉素序贯治疗不同水平PLA2组间患儿的临床效果。结果低PLA2组患儿治疗总有效率为95.24%,显著高于高PLA2组(78.57%),差异有统计学意义(P<0.05);低PLA2组气喘、咳嗽、高烧、肺啰音症状改善时间均显著短于高PLA2组,差异有高度统计学意义(P<0.01);低PLA2组与高PLA2组总体不良反应率差异无统计学意义(P>0.05)。结论低PLA2水平支原体肺炎患儿予以阿奇霉素治疗可取得较好的临床效果。

Objective To investigate the effect of serum phospholipase A2（PLA2） on Azithromycin sequential therapy for children wiht Mycoplasma pneumonia.Methods 84 cases with Mycoplasma pneumonia were recruited from June2015 to December 2016 in Pediatrics Department of People＇s Hospital of Chongzhou.The changes of serum PLA2 were measured.The patients were divided into high/low PLA2 groups according to the median values of PLA2.The clinical efficacy of Azithromycin sequential therapy for Mycoplasma pneumonia was compared between different PLA2 levels groups.Results The overall effective rate of low PLA2 group was 95.24%, which was significantly higher than that in high PLA2 group（78.57%）, with statistically significant difference（P〈 0.05）.The improved time of asthma, cough,fever, pulmonary rales symptom in low PLA2 group were significantly shorter than those in high PLA2 group（P 〈0.01）.There was no significant difference in overall adverse reaction rate between low PLA2 group and high PLA2 group（P〉 0.05）.Conclusion Azithromycin treatment for Mycoplasma pneumonia in children can get better effect in patients with low PLA2 levels.