小型猪在生殖毒性实验中的研究进展

Research progress of minipigs in reproductive toxicity studies

小型猪与人类在解剖学、生理和病理学等方面有很多相似性,具有发情周期短、仔猪数量多等优点,现已成为人类医学研究的理想动物模型,但由于背景数据缺乏、动物体型较大等原因,目前其在生殖毒性实验中并未得到广泛应用。本文根据小型猪自身的特点,对其目前在生殖毒性实验中的应用情况进行综述,旨在扩大非啮齿动物在生殖毒性实验中的选择范围,并在必要时替代犬或非人灵长类动物,为药物非临床生殖毒性试验提供新的研究思路。

As to anatomy and pathophysiology, there are lots of similarities between human and minipig. Because of its short estrus cycle and large number of piglets in a litter, minipig has become an ideal animal model for medical research in human. However, minipig has been restrictedly used in reproductive toxicity studies because of its large body size and limited background data. In this review summarizes the characteristics of minipig as well asits current applications in reproductive toxicity studies, intend to expand the range of selecting non-rodents and provide new ideas for nonclinical reproductive toxicity studies.